School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St. Beitou Dist., Taipei City 112304, Taiwan.
Institute of Public Health, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St. Beitou Dist., Taipei City 112304, Taiwan.
Brief Bioinform. 2024 May 23;25(4). doi: 10.1093/bib/bbae351.
With the increasing prevalence of age-related chronic diseases burdening healthcare systems, there is a pressing need for innovative management strategies. Our study focuses on the gut microbiota, essential for metabolic, nutritional, and immune functions, which undergoes significant changes with aging. These changes can impair intestinal function, leading to altered microbial diversity and composition that potentially influence health outcomes and disease progression. Using advanced metagenomic sequencing, we explore the potential of personalized probiotic supplements in 297 older adults by analyzing their gut microbiota. We identified distinctive Lactobacillus and Bifidobacterium signatures in the gut microbiota of older adults, revealing probiotic patterns associated with various population characteristics, microbial compositions, cognitive functions, and neuroimaging results. These insights suggest that tailored probiotic supplements, designed to match individual probiotic profile, could offer an innovative method for addressing age-related diseases and functional declines. Our findings enhance the existing evidence base for probiotic use among older adults, highlighting the opportunity to create more targeted and effective probiotic strategies. However, additional research is required to validate our results and further assess the impact of precision probiotics on aging populations. Future studies should employ longitudinal designs and larger cohorts to conclusively demonstrate the benefits of tailored probiotic treatments.
随着与年龄相关的慢性疾病对医疗系统负担的增加，迫切需要创新的管理策略。我们的研究集中在肠道微生物群上，它对代谢、营养和免疫功能至关重要，随着年龄的增长，肠道微生物群会发生显著变化。这些变化会损害肠道功能，导致微生物多样性和组成的改变，从而可能影响健康结果和疾病进展。我们使用先进的宏基因组测序技术，通过分析 297 名老年人的肠道微生物群，研究个性化益生菌补充剂的潜力。我们在老年人的肠道微生物群中发现了独特的乳杆菌和双歧杆菌特征，揭示了与各种人群特征、微生物组成、认知功能和神经影像学结果相关的益生菌模式。这些发现表明，针对个体益生菌特征设计的定制益生菌补充剂可能为解决与年龄相关的疾病和功能下降提供一种创新方法。我们的研究结果增强了益生菌在老年人中的应用的现有证据基础，突出了为老年人群创造更有针对性和更有效的益生菌策略的机会。然而，需要进一步的研究来验证我们的结果，并进一步评估精准益生菌对老年人群的影响。未来的研究应采用纵向设计和更大的队列，以明确证明定制益生菌治疗的益处。
