Qin Dahui
Moffitt Cancer Center, Tampa, FL 33612-9416, USA.
Cancer Biol Med. 2021 Aug 4;19(1):4-13. doi: 10.20892/j.issn.2095-3941.2020.0734.
In the era of personalized medicine, information on molecular change at the gene level is important for patient care. Such information has been used for disease classification, diagnosis, prognosis, risk stratification, and treatment, which is especially important in cancer patient care. Many molecular tests exist and can be used to detect the molecular changes at gene level. These tests include, but are not limited to, karyotyping, endpoint polymerase chain reaction (PCR), real-time PCR, Sanger sequencing, pyrosequencing, next-generation sequencing, and so forth. How to use the right tests for the right patients at the right time is essential for optimal patient outcome. This review puts together some information on molecular testing for acute myeloid leukemia.
在个性化医疗时代，基因水平的分子变化信息对患者护理至关重要。此类信息已用于疾病分类、诊断、预后、风险分层及治疗，这在癌症患者护理中尤为重要。存在多种分子检测方法，可用于检测基因水平的分子变化。这些检测方法包括但不限于核型分析、终点聚合酶链反应（PCR）、实时PCR、桑格测序、焦磷酸测序、下一代测序等。在正确的时间为正确的患者选择合适的检测方法对于实现最佳患者治疗效果至关重要。本综述汇集了一些关于急性髓系白血病分子检测的信息。
