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菊粉联合粪菌移植对雏鸡早期肠道免疫功能的影响及潜在机制。

The effect and potential mechanism of inulin combined with fecal microbiota transplantation on early intestinal immune function in chicks.

机构信息

College of Animal Science and Technology, Jilin Agricultural University, No.2888 Xincheng Road, Nanguan District, Changchun, 130118, Jilin, China.

College of Food Science and Engineering, Jilin Agricultural University, Changchun, 130118, Jilin, China.

出版信息

Sci Rep. 2024 Jul 23;14(1):16973. doi: 10.1038/s41598-024-67881-2.

DOI:10.1038/s41598-024-67881-2
PMID:39043769
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11266578/
Abstract

Our previous research found that fecal microbiota transplantation (FMT) and inulin synergistically affected the intestinal barrier and immune system function in chicks. However, does it promote the early immunity of the poultry gut-associated lymphoid tissue (GALT)? How does it regulate the immunity? We evaluated immune-related indicators in the serum, cecal tonsil, and intestine to determine whether FMT synergistic inulin had a stronger impact on gut health and which gene expression regulation was affected. The results showed that FMT synergistic inulin increased TGF-β secretion and intestinal goblet cell number and MUC2 expression on day 14. Expression of BAFFR, PAX5, CXCL12, and IL-2 on day 7 and expression of CXCR4 and IL-2 on day 14 in the cecal tonsils significantly increased. The transcriptome indicated that CD28 and CTLA4 were important regulatory factors in intestinal immunity. Correlation analysis showed that differential genes were related to the immunity and development of the gut and cecal tonsil. FMT synergistic inulin promoted the development of GALT, which improved the early-stage immunity of the intestine by regulating CD28 and CTLA4. This provided new measures for replacing antibiotic use and reducing the use of therapeutic drugs while laying a technical foundation for achieving anti-antibiotic production of poultry products.

摘要

我们之前的研究发现，粪便微生物群移植（FMT）和菊粉协同作用影响雏鸡的肠道屏障和免疫系统功能。然而，它是否能促进家禽肠道相关淋巴组织（GALT）的早期免疫？它是如何调节免疫的？我们评估了血清、盲肠扁桃体和肠道中的免疫相关指标，以确定 FMT 协同菊粉是否对肠道健康有更强的影响，以及哪些基因表达受到影响。结果表明，FMT 协同菊粉在第 14 天增加了 TGF-β 的分泌和肠道杯状细胞的数量以及 MUC2 的表达。第 7 天盲肠扁桃体中 BAFFR、PAX5、CXCL12 和 IL-2 的表达以及第 14 天 CXCR4 和 IL-2 的表达显著增加。转录组表明 CD28 和 CTLA4 是肠道免疫的重要调节因子。相关性分析表明，差异基因与肠道和盲肠扁桃体的免疫和发育有关。FMT 协同菊粉促进了 GALT 的发育，通过调节 CD28 和 CTLA4 改善了肠道的早期免疫。这为替代抗生素使用和减少治疗性药物的使用提供了新的措施，为实现禽产品的抗抗生素生产奠定了技术基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1726/11266578/1aacd6e8a956/41598_2024_67881_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1726/11266578/c1326e75c996/41598_2024_67881_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1726/11266578/6c9b877ebac4/41598_2024_67881_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1726/11266578/9c9d5447fd01/41598_2024_67881_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1726/11266578/9fe897f49fcf/41598_2024_67881_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1726/11266578/8b4d4fbfeaa2/41598_2024_67881_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1726/11266578/4eb14fa2bbd4/41598_2024_67881_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1726/11266578/1aacd6e8a956/41598_2024_67881_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1726/11266578/c1326e75c996/41598_2024_67881_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1726/11266578/6c9b877ebac4/41598_2024_67881_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1726/11266578/9c9d5447fd01/41598_2024_67881_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1726/11266578/9fe897f49fcf/41598_2024_67881_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1726/11266578/8b4d4fbfeaa2/41598_2024_67881_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1726/11266578/4eb14fa2bbd4/41598_2024_67881_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1726/11266578/1aacd6e8a956/41598_2024_67881_Fig7_HTML.jpg

相似文献

[1]
The effect and potential mechanism of inulin combined with fecal microbiota transplantation on early intestinal immune function in chicks.

Sci Rep. 2024-7-23

[2]
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[3]
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[4]
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[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Recent advances in the application of microbiota transplantation in chickens.

J Anim Sci Biotechnol. 2025-6-27

[2]
Cecal microbiota transplantation enhances calcium retention through modulation of gut microbiota and intestinal calcium transporter gene expression in chicks.

Poult Sci. 2025-6-14

本文引用的文献

[1]
In ovo feeding of probiotic lactobacilli differentially alters expression of genes involved in the development and immunological maturation of bursa of Fabricius in pre-hatched chicks.

Poult Sci. 2024-1

[2]
Vertical transmission of gut bacteria in commercial chickens is limited.

Anim Microbiome. 2023-10-10

[3]
Fecal microbiota transplantation improves chicken growth performance by balancing jejunal Th17/Treg cells.

Microbiome. 2023-6-21

[4]
Donor selection for fecal bacterial transplantation and its combined effects with inulin on early growth and ileal development in chicks.

J Appl Microbiol. 2023-5-2

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B Lymphocyte Development in the Bursa of Fabricius of Young Broilers is Influenced by the Gut Microbiota.

Microbiol Spectr. 2023-3-14

[6]
Early life microbiota transplantation from highly feed-efficient broiler improved weight gain by reshaping the gut microbiota in laying chicken.

Front Microbiol. 2022-11-18

[7]
KEGG for taxonomy-based analysis of pathways and genomes.

Nucleic Acids Res. 2023-1-6

[8]
alleviates intestinal inflammation and promotes microbiota-mediated protection against fatal infections.

Front Immunol. 2022

[9]
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation.

Nat Immunol. 2022-9

[10]
Effects of Different Monochromatic Light Combinations on Cecal Microbiota Composition and Cecal Tonsil T Lymphocyte Proliferation.

Front Immunol. 2022

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