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戊二醛处理的虹鳟鱼皮作为大鼠腹疝修补术网片的应用。

Use of rainbow trout skin treated with glutaraldehyde as a mesh for abdominal hernioplasty in rats.

机构信息

Universidade Federal Fluminense - Programa de Pós-graduação em Medicina Veterinária Clínica e Reprodução Animal - Niterói (RJ), Brazil.

Centro Universitário Serra dos Órgãos - Curso de Graduação em Medicina Veterinária - Teresópolis (RJ), Brazil.

出版信息

Acta Cir Bras. 2024 Jul 22;39:e393024. doi: 10.1590/acb393024. eCollection 2024.

DOI:10.1590/acb393024
PMID:39046040
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11262756/
Abstract

PURPOSE

To test the use of rainbow trout skin as a surgical mesh in abdominal hernioplasties in rats.

METHODS

The experiment involved 20 Wistar rats receiving implants of trout skin processed for disinfection in 0.5% glutaraldehyde and preserved in 100% glycerin. The animals were divided into four groups, divided at 7, 15, 30, and 90 days postoperatively. Clinical and infrared thermography evaluations were performed, and after euthanasia, assessments of adhesion formations and sample collection for histological evaluation were conducted.

RESULTS

The implant was observed to be intact, ensuring the integrity of the abdominal wall, support for the viscera, and normal mobility for the rats for up to 90 days. Low rates of clinical alterations were observed, with an intense inflammatory reaction up to day 7, chronic inflammation and the onset of angiogenesis at day 15, and a low inflammatory reaction with collagenous infiltrate and fibrosis at day 30. At day 90, the implants showed a collagenous and fibrotic infiltrate with a minimal inflammatory infiltrate.

CONCLUSIONS

The surgical mesh of trout skin performed well, making it a potential alternative for surgical procedures in muscle aponeurotic corrections in the abdominal wall.

摘要

目的

测试虹鳟鱼皮在大鼠腹壁疝修补术中作为外科补片的应用。

方法

该实验涉及 20 只接受经过 0.5%戊二醛消毒和 100%甘油保存的虹鳟鱼皮植入物的 Wistar 大鼠。动物被分为 4 组，分别在术后 7、15、30 和 90 天进行临床和红外热成像评估，然后进行粘连形成和样本采集以进行组织学评估。

结果

植入物保持完整，确保了腹壁的完整性、内脏的支撑以及大鼠的正常活动度，最长可达 90 天。观察到低水平的临床改变，7 天内出现强烈的炎症反应，15 天内出现慢性炎症和血管生成，30 天内出现低水平炎症反应，伴有胶原浸润和纤维化。90 天时，植入物显示出胶原纤维和纤维组织的浸润，伴有轻微的炎症浸润。

结论

虹鳟鱼皮的外科补片表现良好，可能是腹壁肌肉腱膜矫正手术的一种替代选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a450/11262756/1fa5d86f4cfd/1678-2674-acb-39-e393024-gf12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a450/11262756/28aff8444c2a/1678-2674-acb-39-e393024-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a450/11262756/ce405c783a7b/1678-2674-acb-39-e393024-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a450/11262756/01f78a1a61b9/1678-2674-acb-39-e393024-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a450/11262756/44c1a5ec813f/1678-2674-acb-39-e393024-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a450/11262756/918c9dc809b3/1678-2674-acb-39-e393024-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a450/11262756/cd54109869a3/1678-2674-acb-39-e393024-gf06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a450/11262756/d9c06a0e2ed4/1678-2674-acb-39-e393024-gf07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a450/11262756/1c659069308b/1678-2674-acb-39-e393024-gf08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a450/11262756/c4a35a41d788/1678-2674-acb-39-e393024-gf09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a450/11262756/09fa8b34e1d6/1678-2674-acb-39-e393024-gf10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a450/11262756/e7cf6d594465/1678-2674-acb-39-e393024-gf11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a450/11262756/1fa5d86f4cfd/1678-2674-acb-39-e393024-gf12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a450/11262756/28aff8444c2a/1678-2674-acb-39-e393024-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a450/11262756/ce405c783a7b/1678-2674-acb-39-e393024-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a450/11262756/01f78a1a61b9/1678-2674-acb-39-e393024-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a450/11262756/44c1a5ec813f/1678-2674-acb-39-e393024-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a450/11262756/918c9dc809b3/1678-2674-acb-39-e393024-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a450/11262756/cd54109869a3/1678-2674-acb-39-e393024-gf06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a450/11262756/d9c06a0e2ed4/1678-2674-acb-39-e393024-gf07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a450/11262756/1c659069308b/1678-2674-acb-39-e393024-gf08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a450/11262756/c4a35a41d788/1678-2674-acb-39-e393024-gf09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a450/11262756/09fa8b34e1d6/1678-2674-acb-39-e393024-gf10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a450/11262756/e7cf6d594465/1678-2674-acb-39-e393024-gf11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a450/11262756/1fa5d86f4cfd/1678-2674-acb-39-e393024-gf12.jpg

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