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大鼠疝修补术中气泡塑料的应用:大鼠疝修补术中气泡塑料的使用。

Bubble plastic use in rats hernioplasty: Uso do plástico bolha em hernioplastias de ratos.

作者信息

da Fonseca Jorge Siria, Seabra da Costa Carolina, de Brito Gitirana Lycia, Abidu Figueiredo Marcelo

机构信息

School of Veterinary Medicine, Center of Health Sciences, Centro Universitário Serra dos Órgãos (UNIFESO) - Estr. Venceslau José de Medeiros, 1045 - Prata, Teresópolis, RJ, 25976-345, Brazil.

Library of Integrative Histology, Institute of Biomedical Science-Universidade Federal do Rio de Janeiro (UFRJ) - Avenida Carlos Chagas Filho, 373, Bloco G, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, 21941-902, Brazil.

出版信息

Heliyon. 2023 Aug 28;9(9):e19483. doi: 10.1016/j.heliyon.2023.e19483. eCollection 2023 Sep.

Abstract

PURPOSE

Despite the high frequency of hernioplasties worldwide, their complications and recurrences are still a challenge to be overcome. The search for prostheses that aim to promote the correction of hernia defects has been a challenge. For this purpose, the materials used in hernioplasties must be biocompatible, promote the formation of little or no peritoneal adhesion, possess compatible texture and flexibility, providing the necessary resistance to protect the viscera and allow the movement of the abdomen.

METHODS

The aim of the present study was to evaluate the effectiveness of bubble plastic (low density polyethylene, LDPE) as a material for the correction of hernia in the abdominal wall. For this, twenty male rats (, Wistar variety) were used and divided into four groups of five animals. The animals were evaluated at 7, 15, 30 and 90 days after surgery according to clinical, thermographic and morphological parameters (macroscopic and microscopic).

RESULTS

The results showed that the bubble plastic induced inflammatory reaction in the initial period (7 day), followed by a reduction (30 day) to increase considerably at 90 days after the operation.

CONCLUSION

So, bubble plastic can be used for temporary implants (up to 30 days).

摘要

目的

尽管全世界疝修补术的实施频率很高,但其并发症和复发仍是有待克服的挑战。寻找旨在促进疝缺损矫正的假体一直是一项挑战。为此,疝修补术中使用的材料必须具有生物相容性,促进极少或不形成腹膜粘连,具备合适的质地和柔韧性,提供保护内脏所需的阻力并允许腹部活动。

方法

本研究的目的是评估泡沫塑料(低密度聚乙烯,LDPE)作为腹壁疝矫正材料的有效性。为此,使用了20只雄性大鼠(Wistar品系),并将其分为四组,每组五只动物。术后7天、15天、30天和90天根据临床、热成像和形态学参数(宏观和微观)对动物进行评估。

结果

结果表明,泡沫塑料在初期(7天)引发炎症反应,随后减轻(30天),在术后90天又大幅增加。

结论

因此,泡沫塑料可用于临时植入(最长30天)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3139/10558621/088adc3222c0/gr1.jpg

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