Mohan Viswanathan, Manasa Valangaiman Sriram, Abirami Kuzhandaivelu, Unnikrishnan Ranjit, Gayathri Rajagopal, Geetha Gunasekaran, RamyaBai Mookambika, Padmavathi Soundararajan, Rajalakshmi Marimuthu, Pradeepa Rajendra, Anjana Ranjit Mohan, Krishnaswamy Kamala, Sudha Vasudevan
Madras Diabetes Research Foundation (ICMR Centre for Advanced Research on Diabetes) and Dr Mohan's Specialities Centre (IDF Centre of Excellence in Diabetes Care), Chennai, 600086, India.
Department of Foods, Nutrition and Dietetics Research, Madras Diabetes Research Foundation, Chennai, Tamil Nadu, India.
Diabetes Ther. 2024 Sep;15(9):2061-2077. doi: 10.1007/s13300-024-01622-6. Epub 2024 Jul 24.
Country-specific evidence-based research is crucial for understanding the role of nonnutritive sweeteners (NNS) in managing type 2 diabetes (T2D). The main aim of this study was to explore the effect of replacing sucrose with sucralose in coffee/tea in Asian Indians with type 2 diabetes (T2D).
This 12-week, parallel-arm randomized controlled trial included 210 participants with T2D, assigned to the intervention group, where sugar/sucrose in coffee or tea was substituted with sucralose, or the control group, where sugar/sucrose was continued. Lifestyle factors remained unchanged. The primary outcome was change in HbA1c. Secondary outcomes were changes in body weight (BW), body mass index (BMI), waist circumference (WC), lipid profiles, and inflammatory markers.
At the end of 12 weeks, no change was observed in HbA1c, fasting plasma glucose, lipid profile, and inflammatory markers between or within groups. There was a small but significant reduction in BW (- 0.5 kg [95% CI - 1.0, - 0.1]; p = 0.02), BMI (- 0.2 kg/m [- 0.4, 0.0]; p = 0.03), and WC (- 0.8 cm [- 1.4, - 0.3]; p = 0.002) in the intervention group. Improvements were also observed in lipid accumulation product (p = 0.01), visceral adiposity index (p = 0.04), triglyceride/glucose index (p = 0.04), total energy intake (p = 0.04), and carbohydrate intake (p < 0.0001).
In Asian Indians with T2D, replacing about 60 kcal of added sucrose with sucralose in coffee/ tea had no benefit on glycemia but resulted in a small reduction in body weight, body mass index, and waist circumference.
Clinical Trials Registry of India (CTRI/2021/04/032686).
特定国家的循证研究对于理解非营养性甜味剂（NNS）在2型糖尿病（T2D）管理中的作用至关重要。本研究的主要目的是探讨在患有2型糖尿病（T2D）的亚洲印度人中，用三氯蔗糖替代咖啡/茶中的蔗糖的效果。
这项为期12周的平行组随机对照试验纳入了210名2型糖尿病患者，分为干预组（用三氯蔗糖替代咖啡或茶中的糖/蔗糖）和对照组（继续使用糖/蔗糖）。生活方式因素保持不变。主要结局是糖化血红蛋白（HbA1c）的变化。次要结局包括体重（BW）、体重指数（BMI）、腰围（WC）、血脂谱和炎症标志物的变化。
在12周结束时，组间和组内的HbA1c、空腹血糖、血脂谱和炎症标志物均未观察到变化。干预组的体重（-0.5千克[95%置信区间-1.0，-0.1]；p=0.02）、BMI（-0.2千克/米[-0.4，0.0]；p=0.03）和WC（-0.8厘米[-1.4，-0.3]；p=0.002）有小幅但显著的下降。脂质蓄积产物（p=0.01）、内脏脂肪指数（p=0.04）、甘油三酯/葡萄糖指数（p=0.04）、总能量摄入（p=0.04）和碳水化合物摄入（p<0.0001）也有改善。
在患有2型糖尿病的亚洲印度人中，用三氯蔗糖替代咖啡/茶中约60千卡的添加蔗糖对血糖没有益处，但会导致体重、体重指数和腰围小幅下降。
印度临床试验注册中心（CTRI/2021/04/032686）。
