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非编码RNA在癌症中的分子机制及临床意义

Molecular Mechanisms and Clinical Implications of Noncoding RNAs in Cancer.

作者信息

Wang Jin, He Xiaomeng, Corpe Christopher

机构信息

Central Laboratory, Zhongshan Hospital (Xiamen), Fudan University, Xiamen 361015, China.

Shanghai Public Health Clinical Center, Fudan University, 2901 Caolang Road, Jinshan District, Shanghai 201508, China.

出版信息

Noncoding RNA. 2024 Jun 25;10(4):37. doi: 10.3390/ncrna10040037.

Abstract

Noncoding RNAs (ncRNAs), which include small nuclear RNAs (snRNAs), small nucleolar RNAs (snoRNAs), microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), are RNA molecules that arise from genomic regions without protein-coding potential and display a variety of mechanisms and functions by regulating gene expression at the transcriptional, RNA processing, and translational levels and participating in virtually all cellular processes [...].

摘要

非编码RNA(ncRNAs),包括小核RNA(snRNAs)、小核仁RNA(snoRNAs)、微小RNA(miRNAs)、长链非编码RNA(lncRNAs)和环状RNA(circRNAs),是由不具有蛋白质编码潜能的基因组区域产生的RNA分子,它们通过在转录、RNA加工和翻译水平上调节基因表达并参与几乎所有细胞过程,展现出多种机制和功能[……]

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00eb/11270368/082675f9c8b6/ncrna-10-00037-g001.jpg

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