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非编码RNA在癌症中的分子机制及临床意义

Molecular Mechanisms and Clinical Implications of Noncoding RNAs in Cancer.

作者信息

Wang Jin, He Xiaomeng, Corpe Christopher

机构信息

Central Laboratory, Zhongshan Hospital (Xiamen), Fudan University, Xiamen 361015, China.

Shanghai Public Health Clinical Center, Fudan University, 2901 Caolang Road, Jinshan District, Shanghai 201508, China.

出版信息

Noncoding RNA. 2024 Jun 25;10(4):37. doi: 10.3390/ncrna10040037.

DOI:10.3390/ncrna10040037
PMID:39051371
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11270368/
Abstract

Noncoding RNAs (ncRNAs), which include small nuclear RNAs (snRNAs), small nucleolar RNAs (snoRNAs), microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), are RNA molecules that arise from genomic regions without protein-coding potential and display a variety of mechanisms and functions by regulating gene expression at the transcriptional, RNA processing, and translational levels and participating in virtually all cellular processes [...].

摘要

非编码RNA（ncRNAs），包括小核RNA（snRNAs）、小核仁RNA（snoRNAs）、微小RNA（miRNAs）、长链非编码RNA（lncRNAs）和环状RNA（circRNAs），是由不具有蛋白质编码潜能的基因组区域产生的RNA分子，它们通过在转录、RNA加工和翻译水平上调节基因表达并参与几乎所有细胞过程，展现出多种机制和功能[……]

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00eb/11270368/082675f9c8b6/ncrna-10-00037-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00eb/11270368/082675f9c8b6/ncrna-10-00037-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00eb/11270368/082675f9c8b6/ncrna-10-00037-g001.jpg

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本文引用的文献

1
Possible Involvement of Long Non-Coding RNAs and in the Modulation of 5-Fluorouracil Chemosensitivity in Colon Cancer Cells through Increased Extracellular Release of Exosomes.长链非编码RNA可能通过增加外泌体的细胞外释放参与结肠癌细胞中5-氟尿嘧啶化疗敏感性的调节。
Noncoding RNA. 2024 Apr 15;10(2):25. doi: 10.3390/ncrna10020025.
2
MiR-4646-5p Acts as a Tumor-Suppressive Factor in Triple Negative Breast Cancer and Targets the Cholesterol Transport Protein GRAMD1B.MiR-4646-5p在三阴性乳腺癌中作为肿瘤抑制因子发挥作用，并靶向胆固醇转运蛋白GRAMD1B。
Noncoding RNA. 2023 Dec 26;10(1):2. doi: 10.3390/ncrna10010002.
3
Discovery of Novel miRNAs in Colorectal Cancer: Potential Biological Roles and Clinical Utility.
结直肠癌中新型微小RNA的发现：潜在生物学作用及临床应用
Noncoding RNA. 2023 Oct 26;9(6):65. doi: 10.3390/ncrna9060065.
4
Crosstalk between Non-Coding RNAs and Wnt/β-Catenin Signaling in Head and Neck Cancer: Identification of Novel Biomarkers and Therapeutic Agents.头颈部癌中非编码RNA与Wnt/β-连环蛋白信号通路之间的串扰：新型生物标志物和治疗药物的鉴定
Noncoding RNA. 2023 Oct 17;9(5):63. doi: 10.3390/ncrna9050063.
5
Structural Modifications and Novel Protein-Binding Sites in Pre-miR-675-Explaining Its Regulatory Mechanism in Carcinogenesis.前体miR-675中的结构修饰和新型蛋白质结合位点——解释其在致癌过程中的调控机制
Noncoding RNA. 2023 Aug 10;9(4):45. doi: 10.3390/ncrna9040045.
6
Non-Coding RNAs in Human Health and Diseases.非编码 RNA 在人类健康与疾病中的作用
Genes (Basel). 2023 Jul 11;14(7):1429. doi: 10.3390/genes14071429.
7
Exosomal lncRNA LINC01268 promotes pancreatic cancer progression via the miR-217-KIF2A-PI3K/AKT axis.外泌体长链非编码RNA LINC01268通过miR-217-KIF2A-PI3K/AKT轴促进胰腺癌进展。
Genes Dis. 2023 Apr 18;10(5):1799-1801. doi: 10.1016/j.gendis.2022.12.018. eCollection 2023 Sep.
8
Functional Relevance of the Long Intergenic Non-Coding RNA Regulator of Reprogramming (Linc-ROR) in Cancer Proliferation, Metastasis, and Drug Resistance.重编程长链基因间非编码RNA调节因子（Linc-ROR）在癌症增殖、转移和耐药中的功能相关性
Noncoding RNA. 2023 Jan 31;9(1):12. doi: 10.3390/ncrna9010012.
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Carcinogenesis. 2023 May 26;44(2):153-165. doi: 10.1093/carcin/bgac102.
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Identification of prognostic immune-related lncRNAs in pancreatic cancer.鉴定胰腺癌中具有预后价值的免疫相关 lncRNAs。
Front Immunol. 2022 Nov 7;13:1005695. doi: 10.3389/fimmu.2022.1005695. eCollection 2022.