Department of Obstetrics and Gynecology, Department of Gynecologic Oncology Research Office, Guangzhou Key Laboratory of Targeted Therapy for Gynecologic Oncology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, The Third Affiliated Hospital of Guangzhou Medical University, No.63 Duobao Road, Liwan District, Guangdong Province, Guangzhou City, 510150, People's Republic of China.
Cell Commun Signal. 2023 Aug 3;21(1):191. doi: 10.1186/s12964-023-01206-0.
In recent years, increasingly more non-coding RNAs have been detected with the development of high-throughput sequencing technology, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), small nucleolar RNAs (snoRNAs), and piwi-interacting RNA (piRNAs). The discovery of enhancer RNAs (eRNAs) in 2010 has further broadened the range of non-coding RNAs revealed. eRNAs are non-coding RNA molecules produced by the transcription of DNA cis-acting elements, enhancer fragments. Recent studies revealed that the transcription of eRNAs may be a biological marker responding to enhancer activity that can participate in the regulation of coding gene transcription. In this review, we discussed the biological characteristics of eRNAs, their functions in transcriptional regulation, the regulation factors of eRNAs production, and the research progress of eRNAs in different diseases. Video Abstract.
近年来，随着高通量测序技术的发展，越来越多的非编码 RNA 被检测到，包括 microRNAs (miRNAs)、长非编码 RNA (lncRNAs)、环状 RNA (circRNAs)、小核仁 RNA (snoRNAs) 和 piwi 相互作用 RNA (piRNAs)。2010 年增强子 RNA (eRNAs) 的发现进一步拓宽了揭示的非编码 RNA 范围。eRNAs 是由 DNA 顺式作用元件、增强子片段转录产生的非编码 RNA 分子。最近的研究表明，eRNAs 的转录可能是一种对增强子活性有反应的生物学标记，可以参与编码基因转录的调控。在这篇综述中，我们讨论了 eRNAs 的生物学特性、它们在转录调控中的功能、eRNAs 产生的调节因子，以及 eRNAs 在不同疾病中的研究进展。视频摘要。
