Department of Pharmaceutics, College of Pharmacy, King Khalid University, 61421, Abha, Saudi Arabia.
Department of Pharmaceutics, Yenepoya Pharmacy College & Research Centre, Yenepoya (Deemed to be University), Mangalore, 575018, Karnataka, India.
AAPS PharmSciTech. 2023 Nov 16;24(8):233. doi: 10.1208/s12249-023-02670-0.
Blood cancer, also known as hematological malignancy, is one of the devastating types of cancer that has significantly paved its mortality mark globally. It persists as an extremely deadly cancer type and needs utmost attention owing to its negligible overall survival rate. Major challenges in the treatment of blood cancer include difficulties in early diagnosis, as well as severe side effects resulting from chemotherapy. In addition, immunotherapies and targeted therapies can be prohibitively expensive. Over the past two decades, scientists have devised a few nanoparticle-based drug delivery systems aimed at overcoming this challenge. These therapeutic strategies are engineered to augment the cellular uptake, pharmacokinetics, and effectiveness of anticancer drugs. However, there are still numerous types of nanoparticles that could potentially improve the efficacy of blood cancer treatment, while also reducing treatment costs and mitigating drug-related side effects. To the best of our knowledge, there has been limited reviews published on the use of nano-based drug delivery systems for the treatment of hematological malignancies. Therefore, we have made a concerted effort to provide a comprehensive review that draws upon recent literature and patents, with a focus on the most promising results regarding the use of nanoparticle-based approaches for the treatment of hematological malignancies. All these crucial points covered under a common title would significantly help researchers and scientists working in the area.
血液癌症，也称为血液恶性肿瘤，是一种极具破坏性的癌症类型，在全球范围内造成了显著的死亡率。它是一种极其致命的癌症类型，由于总体生存率极低，因此需要高度关注。血液癌症治疗面临的主要挑战包括早期诊断困难，以及化疗引起的严重副作用。此外，免疫疗法和靶向疗法可能非常昂贵。在过去的二十年中，科学家们设计了几种基于纳米粒子的药物输送系统，旨在克服这一挑战。这些治疗策略旨在增强抗癌药物的细胞摄取、药代动力学和效果。然而，仍有许多类型的纳米粒子可能会提高血液癌症治疗的效果，同时降低治疗成本并减轻药物相关的副作用。据我们所知，目前已经发表了一些关于使用纳米药物输送系统治疗血液恶性肿瘤的综述，但对于基于纳米粒子的方法治疗血液恶性肿瘤的最有前途的结果，仍缺乏综述。因此，我们集中精力提供了一份全面的综述，参考了最近的文献和专利，重点介绍了基于纳米粒子的方法治疗血液恶性肿瘤的最有前途的结果。所有这些关键要点都在一个共同的标题下进行了讨论，这将对该领域的研究人员和科学家有很大的帮助。
