Villarreal Rizzo Alan F, Davis Elizabeth I, Khalife Wissam I, Peek M Kristen, Downer Brian
Division of Internal Medicine, Mayo Clinic School of Graduate Medical Education, Rochester, MN, USA.
Division of Cardiovascular Medicine, The University of Texas Medical Branch, Galveston, TX, USA.
Int J Cardiol Cardiovasc Risk Prev. 2024 Jul 3;22:200309. doi: 10.1016/j.ijcrp.2024.200309. eCollection 2024 Sep.
Studies of adult populations in high-income countries have found an association between arthritis and myocardial infarction (MI) due to high levels of systemic inflammation. Our objectives were to examine the association between arthritis and MI among Mexican adults and to assess the mediating effect of C-reactive protein (CRP) on this association.
Data came from the 2012, 2015, and 2018 observation waves of the Mexican Health and Aging Study. Our sample included 11,707 participants aged 50 and older with no prior MI before 2012. We used self-reported information for arthritis, joint pain, medication use, and limitations to daily activities in 2012. Logistic regression was used to model the association between arthritis and self-reported MI in 2015 or 2018. We used a sub-sample of 1602 participants to assess the mediating effect of CRP.
In the full sample, participants with arthritis that limited their daily activities had higher odds of MI than participants with no arthritis (OR = 1.40; 95 % CI = 1.04-1.88). In the sub-sample, arthritis that limited daily activities was associated with higher mean CRP (5.2 mg/dL; 95 % CI = 4.10-6.21) than arthritis with no limitations (3.5 mg/dL; 95 % CI = 2.93-4.01). However, CRP levels had a small mediating effect, and the relationship between arthritis with physical limitations and MI remained statistically significant.
Mexican adults with arthritis that limits their daily activities are at an increased risk for MI. Continued research is needed to identify factors that contribute to this increased risk.
在高收入国家对成年人群的研究发现，由于全身炎症水平较高，关节炎与心肌梗死（MI）之间存在关联。我们的目标是研究墨西哥成年人中关节炎与心肌梗死之间的关联，并评估C反应蛋白（CRP）对这种关联的中介作用。
数据来自墨西哥健康与老龄化研究2012年、2015年和2018年的观察期。我们的样本包括11707名50岁及以上且在2012年之前无心肌梗死病史的参与者。我们使用了2012年关于关节炎、关节疼痛、药物使用和日常活动受限的自我报告信息。采用逻辑回归模型分析2015年或2018年关节炎与自我报告的心肌梗死之间的关联。我们使用1602名参与者的子样本评估CRP的中介作用。
在整个样本中，日常活动受限的关节炎患者发生心肌梗死的几率高于无关节炎患者（OR = 1.40；95%CI = 1.04 - 1.88）。在子样本中，日常活动受限的关节炎患者的平均CRP水平（5.2mg/dL；95%CI = 4.10 - 6.21）高于无活动受限的关节炎患者（3.5mg/dL；95%CI = 2.93 - 4.01）。然而，CRP水平的中介作用较小，身体受限的关节炎与心肌梗死之间的关系仍具有统计学意义。
日常活动受限的墨西哥关节炎成年人发生心肌梗死的风险增加。需要继续开展研究以确定导致这种风险增加的因素。
