• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

大肠杆菌的肠道黏附菌毛和肠毒素：向鼠伤寒沙门氏菌Ty21a galE口服活疫苗链霉素抗性突变体的基因转移。

Enteroadhesion fimbriae and enterotoxin of Escherichia coli: genetic transfer to a streptomycin-resistant mutant of the galE oral-route live-vaccine Salmonella typhi Ty21a.

作者信息

Yamamoto T, Tamura Y, Yokota T

出版信息

Infect Immun. 1985 Dec;50(3):925-8. doi: 10.1128/iai.50.3.925-928.1985.

DOI:10.1128/iai.50.3.925-928.1985
PMID:3905619
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC261171/
Abstract

An enterotoxigenic Escherichia coli plasmid encoding colonization factor antigen (CFA) I fimbriae and heat-stable toxin was transferred into a streptomycin-resistant mutant of the Salmonella typhi galE strain Ty21a (a live attenuated oral typhoid vaccine). The virulence plasmid-carrying transconjugants produced CFA I fimbriae and heat-stable toxin. The marked production of CFA I fimbriae was observed even in a vaccine medium for Ty21a. The data lead to a new type of potential live oral vaccine, S. typhi Ty21a producing enteroadhesion fimbriae.

摘要

一种编码定居因子抗原（CFA）I菌毛和热稳定毒素的产肠毒素大肠杆菌质粒被转入鼠伤寒沙门氏菌galE菌株Ty21a（一种减毒口服伤寒疫苗）的链霉素抗性突变体中。携带毒力质粒的接合子产生CFA I菌毛和热稳定毒素。即使在Ty21a的疫苗培养基中也观察到了CFA I菌毛的显著产生。这些数据导致了一种新型的潜在减毒口服疫苗——产肠黏附菌毛的鼠伤寒沙门氏菌Ty21a。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208a/261171/5c46e24bb1b2/iai00111-0335-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208a/261171/4e9439f25b61/iai00111-0334-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208a/261171/5c46e24bb1b2/iai00111-0335-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208a/261171/4e9439f25b61/iai00111-0334-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/208a/261171/5c46e24bb1b2/iai00111-0335-a.jpg

相似文献

1
Enteroadhesion fimbriae and enterotoxin of Escherichia coli: genetic transfer to a streptomycin-resistant mutant of the galE oral-route live-vaccine Salmonella typhi Ty21a.大肠杆菌的肠道黏附菌毛和肠毒素：向鼠伤寒沙门氏菌Ty21a galE口服活疫苗链霉素抗性突变体的基因转移。
Infect Immun. 1985 Dec;50(3):925-8. doi: 10.1128/iai.50.3.925-928.1985.
2
A virulence plasmid in Escherichia coli enterotoxigenic for humans: intergenetic transfer and expression.一种对人类具有肠毒素致病性的大肠杆菌中的毒力质粒：基因间转移与表达。
J Infect Dis. 1984 Nov;150(5):688-98. doi: 10.1093/infdis/150.5.688.
3
Plasmids coding for colonization factor antigen I and heat-stable enterotoxin production isolated from enterotoxigenic Escherichia coli: comparison of their properties.从产肠毒素大肠杆菌中分离出的编码定居因子抗原I和产热稳定肠毒素的质粒：其特性比较
Infect Immun. 1981 May;32(2):927-36. doi: 10.1128/iai.32.2.927-936.1981.
4
Construction of a potential live oral bivalent vaccine for typhoid fever and cholera-Escherichia coli-related diarrheas.用于伤寒、霍乱及大肠杆菌相关腹泻的潜在口服活二价疫苗的构建。
Infect Immun. 1984 Nov;46(2):564-9. doi: 10.1128/iai.46.2.564-569.1984.
5
Biotypes, antibiotic resistance and plasmids coding for CFA/I and STa in enterotoxigenic Escherichia coli strains of serotype O153:H45 isolated in Spain.在西班牙分离出的血清型为O153:H45的产肠毒素大肠杆菌菌株中的生物型、抗生素抗性以及编码CFA/I和STa的质粒
J Med Microbiol. 1991 Feb;34(2):89-95. doi: 10.1099/00222615-34-2-89.
6
Use of the alpha-hemolysin secretion system of Escherichia coli for antigen delivery in the Salmonella typhi Ty21a vaccine strain.利用大肠杆菌的α-溶血素分泌系统在伤寒沙门氏菌Ty21a疫苗株中递送抗原。
Int J Med Microbiol. 2004 Oct;294(6):363-71. doi: 10.1016/j.ijmm.2004.07.010.
7
Improvement of the live vaccine strain Salmonella enterica serovar Typhi Ty21a for antigen delivery via the hemolysin secretion system of Escherichia coli.通过大肠杆菌溶血素分泌系统递送抗原对减毒活疫苗株肠炎沙门氏菌伤寒血清型Ty21a进行改造。
Int J Med Microbiol. 2009 Feb;299(2):109-19. doi: 10.1016/j.ijmm.2008.06.006. Epub 2008 Aug 15.
8
Plasmids coding for colonization factor antigens I and II, heat-labile enterotoxin, and heat-stable enterotoxin A2 in Escherichia coli.编码大肠杆菌中定居因子抗原I和II、不耐热肠毒素以及耐热肠毒素A2的质粒。
Infect Immun. 1986 Feb;51(2):626-30. doi: 10.1128/iai.51.2.626-630.1986.
9
Simultaneous expression of CFA/I and CS3 colonization factor antigens of enterotoxigenic Escherichia coli by delta aroC, delta aroD Salmonella typhi vaccine strain CVD 908.通过缺失aroC、缺失aroD的伤寒沙门氏菌疫苗株CVD 908同时表达产肠毒素大肠杆菌的CFA/I和CS3定居因子抗原。
Vaccine. 1995 Jul;13(10):939-46. doi: 10.1016/0264-410x(95)00003-j.
10
Attenuated typhoid vaccine Salmonella typhi Ty21a: fingerprinting and quality control.减毒伤寒疫苗伤寒沙门菌Ty21a：指纹图谱与质量控制。
Microbiology (Reading). 1995 Aug;141 ( Pt 8):1993-2002. doi: 10.1099/13500872-141-8-1993.

引用本文的文献

1
Novel antigens for enterotoxigenic Escherichia coli vaccines.肠毒素性大肠杆菌疫苗的新型抗原。
Expert Rev Vaccines. 2014 May;13(5):631-9. doi: 10.1586/14760584.2014.905745. Epub 2014 Apr 4.
2
Oral vaccination with salmonella simultaneously expressing Yersinia pestis F1 and V antigens protects against bubonic and pneumonic plague.用同时表达鼠疫耶尔森菌F1和V抗原的沙门氏菌进行口服疫苗接种可预防腺鼠疫和肺鼠疫。
J Immunol. 2007 Jan 15;178(2):1059-67. doi: 10.4049/jimmunol.178.2.1059.
3
Oral immunization with a Salmonella typhimurium vaccine vector expressing recombinant enterotoxigenic Escherichia coli K99 fimbriae elicits elevated antibody titers for protective immunity.

本文引用的文献

1
R-factor-mediated suppression of the galactose-sensitive phenotype of Escherichia coli K-12 galE Mutants.R因子介导的大肠杆菌K-12 galE突变体半乳糖敏感表型的抑制作用。
Plasmid. 1981 Jul;6(1):78-85. doi: 10.1016/0147-619x(81)90055-x.
2
Cloning of deoxyribonucleic acid regions encoding a heat-labile and heat-stable enterotoxin originating from an enterotoxigenic Escherichia coli strain of human origin.对源自人源产肠毒素大肠杆菌菌株的编码不耐热和耐热肠毒素的脱氧核糖核酸区域进行克隆。
J Bacteriol. 1980 Aug;143(2):652-60. doi: 10.1128/jb.143.2.652-660.1980.
3
A controlled field trial of liver oral typhoid vaccine Ty21a.
用表达重组产肠毒素大肠杆菌K99菌毛的鼠伤寒沙门氏菌疫苗载体进行口服免疫可引发用于保护性免疫的抗体滴度升高。
Infect Immun. 1998 Nov;66(11):5470-6. doi: 10.1128/IAI.66.11.5470-5476.1998.
4
Advances in vaccines for typhoid fever.伤寒疫苗的进展。
Indian J Pediatr. 1994 Jul-Aug;61(4):321-39. doi: 10.1007/BF02751884.
5
Immune responses to novel Escherichia coli and Salmonella typhimurium vectors that express colonization factor antigen I (CFA/I) of enterotoxigenic E. coli in the absence of the CFA/I positive regulator cfaR.针对新型大肠杆菌和鼠伤寒沙门氏菌载体的免疫反应，这些载体在缺乏CFA/I阳性调节因子cfaR的情况下表达产肠毒素大肠杆菌的定居因子抗原I（CFA/I）。
Infect Immun. 1995 Dec;63(12):4933-8. doi: 10.1128/iai.63.12.4933-4938.1995.
6
Purification, morphology, and genetics of a new fimbrial putative colonization factor of enterotoxigenic Escherichia coli O159:H4.产肠毒素大肠杆菌O159:H4一种新的菌毛假定定植因子的纯化、形态学及遗传学研究
Infect Immun. 1987 May;55(5):1063-9. doi: 10.1128/iai.55.5.1063-1069.1987.
7
Effect of a purA mutation on efficacy of Salmonella live-vaccine vectors.purA突变对沙门氏菌活疫苗载体效力的影响。
Infect Immun. 1989 Jun;57(6):1858-61. doi: 10.1128/iai.57.6.1858-1861.1989.
8
Probing the topology of a bacterial membrane protein by genetic insertion of a foreign epitope; expression at the cell surface.通过外源表位的基因插入探究细菌膜蛋白的拓扑结构；在细胞表面的表达
EMBO J. 1986 Nov;5(11):3029-37. doi: 10.1002/j.1460-2075.1986.tb04602.x.
9
Safety, immunogenicity, and efficacy against cholera challenge in humans of a typhoid-cholera hybrid vaccine derived from Salmonella typhi Ty21a.源自伤寒杆菌Ty21a的伤寒-霍乱杂交疫苗在人体中的安全性、免疫原性及抗霍乱攻击效力。
Infect Immun. 1990 Jun;58(6):1620-7. doi: 10.1128/iai.58.6.1620-1627.1990.
口服伤寒疫苗Ty21a的对照现场试验。
Bull World Health Organ. 1980;58(3):469-74.
4
Construction of a potential live oral bivalent vaccine for typhoid fever and cholera-Escherichia coli-related diarrheas.用于伤寒、霍乱及大肠杆菌相关腹泻的潜在口服活二价疫苗的构建。
Infect Immun. 1984 Nov;46(2):564-9. doi: 10.1128/iai.46.2.564-569.1984.
5
Plasmids of enterotoxigenic Escherichia coli H10407: evidence for two heat-stable enterotoxin genes and a conjugal transfer system.产肠毒素大肠杆菌H10407的质粒：两个耐热肠毒素基因及一个接合转移系统的证据
J Bacteriol. 1983 Mar;153(3):1352-60. doi: 10.1128/jb.153.3.1352-1360.1983.
6
Construction of a potential bivalent vaccine strain: introduction of Shigella sonnei form I antigen genes into the galE Salmonella typhi Ty21a typhoid vaccine strain.一种潜在二价疫苗株的构建：将宋内志贺菌I型抗原基因导入伤寒疫苗株鼠伤寒沙门菌Ty21a的galE基因中。
Infect Immun. 1981 Dec;34(3):746-50. doi: 10.1128/iai.34.3.746-750.1981.
7
A virulence plasmid in Escherichia coli enterotoxigenic for humans: intergenetic transfer and expression.一种对人类具有肠毒素致病性的大肠杆菌中的毒力质粒：基因间转移与表达。
J Infect Dis. 1984 Nov;150(5):688-98. doi: 10.1093/infdis/150.5.688.
8
Host-specific fimbrial adhesins of noninvasive enterotoxigenic Escherichia coli strains.非侵袭性产肠毒素大肠杆菌菌株的宿主特异性菌毛黏附素。
Microbiol Rev. 1982 Jun;46(2):129-61. doi: 10.1128/mr.46.2.129-161.1982.
9
New fimbrial antigenic type (E8775) that may represent a colonization factor in enterotoxigenic Escherichia coli in humans.新的菌毛抗原型（E8775），可能是人类产肠毒素大肠杆菌中的一种定植因子。
Infect Immun. 1982 Mar;35(3):1119-24. doi: 10.1128/iai.35.3.1119-1124.1982.
10
Enterotoxigenic Escherichia coli: identification and characterization.产肠毒素大肠杆菌：鉴定与特性分析
J Infect Dis. 1980 Aug;142(2):279-86. doi: 10.1093/infdis/142.2.279.