铁死亡在EB病毒相关癌症中的新作用：对癌症治疗的启示
The Emerging Role of Ferroptosis in EBV-Associated Cancer: Implications for Cancer Therapy.
作者信息
He Shan, Luo Cheng, Shi Feng, Zhou Jianhua, Shang Li
机构信息
Key Laboratory of Carcinogenesis and Cancer Invasion of Chinese Ministry of Education, XiangYa Hospital, Central South University, Changsha 410078, China.
Department of Pathology, National Clinical Research Center for Geriatric Disorders/XiangYa Hospital, Central South University, Changsha 410078, China.
出版信息
Biology (Basel). 2024 Jul 18;13(7):543. doi: 10.3390/biology13070543.
Ferroptosis is a novel and iron-dependent form of programmed cell death, which has been implicated in the pathogenesis of various human cancers. EBV is a well-recognized oncogenic virus that controls multiple signaling pathways within the host cell, including ferroptosis signaling. Recent studies show that inducing ferroptosis could be an efficient therapeutic strategy for EBV-associated tumors. This review will firstly describe the mechanism of ferroptosis, then summarize EBV infection and EBV-associated tumors, as well as the crosstalk between EBV infection and the ferroptosis signaling pathway, and finally discuss the role and potential application of ferroptosis-related reagents in EBV-associated tumors.
铁死亡是一种新的、铁依赖性的程序性细胞死亡形式，已被认为与多种人类癌症的发病机制有关。EB病毒是一种公认的致癌病毒，它控制宿主细胞内的多种信号通路，包括铁死亡信号通路。最近的研究表明，诱导铁死亡可能是治疗EB病毒相关肿瘤的一种有效策略。这篇综述将首先描述铁死亡的机制，然后总结EB病毒感染和EB病毒相关肿瘤，以及EB病毒感染与铁死亡信号通路之间的相互作用，最后讨论铁死亡相关试剂在EB病毒相关肿瘤中的作用和潜在应用。
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