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铁死亡在EB病毒相关癌症中的新作用：对癌症治疗的启示

The Emerging Role of Ferroptosis in EBV-Associated Cancer: Implications for Cancer Therapy.

作者信息

He Shan, Luo Cheng, Shi Feng, Zhou Jianhua, Shang Li

机构信息

Key Laboratory of Carcinogenesis and Cancer Invasion of Chinese Ministry of Education, XiangYa Hospital, Central South University, Changsha 410078, China.

Department of Pathology, National Clinical Research Center for Geriatric Disorders/XiangYa Hospital, Central South University, Changsha 410078, China.

出版信息

Biology (Basel). 2024 Jul 18;13(7):543. doi: 10.3390/biology13070543.

DOI:10.3390/biology13070543
PMID:39056735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11274159/
Abstract

Ferroptosis is a novel and iron-dependent form of programmed cell death, which has been implicated in the pathogenesis of various human cancers. EBV is a well-recognized oncogenic virus that controls multiple signaling pathways within the host cell, including ferroptosis signaling. Recent studies show that inducing ferroptosis could be an efficient therapeutic strategy for EBV-associated tumors. This review will firstly describe the mechanism of ferroptosis, then summarize EBV infection and EBV-associated tumors, as well as the crosstalk between EBV infection and the ferroptosis signaling pathway, and finally discuss the role and potential application of ferroptosis-related reagents in EBV-associated tumors.

摘要

铁死亡是一种新的、铁依赖性的程序性细胞死亡形式，已被认为与多种人类癌症的发病机制有关。EB病毒是一种公认的致癌病毒，它控制宿主细胞内的多种信号通路，包括铁死亡信号通路。最近的研究表明，诱导铁死亡可能是治疗EB病毒相关肿瘤的一种有效策略。这篇综述将首先描述铁死亡的机制，然后总结EB病毒感染和EB病毒相关肿瘤，以及EB病毒感染与铁死亡信号通路之间的相互作用，最后讨论铁死亡相关试剂在EB病毒相关肿瘤中的作用和潜在应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a801/11274159/5eab1387b278/biology-13-00543-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a801/11274159/a16cf1968430/biology-13-00543-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a801/11274159/5eab1387b278/biology-13-00543-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a801/11274159/a16cf1968430/biology-13-00543-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a801/11274159/5eab1387b278/biology-13-00543-g002.jpg

相似文献

[1]
The Emerging Role of Ferroptosis in EBV-Associated Cancer: Implications for Cancer Therapy.

Biology (Basel). 2024-7-18

[2]
polysaccharides induce ferroptosis in Epstein-Barr virus-associated gastric cancer by inactivating NRF2/HO-1 signaling.

Aging (Albany NY). 2024-1-19

[3]
Epstein-Barr virus latency programs dynamically sensitize B cells to ferroptosis.

Proc Natl Acad Sci U S A. 2022-3-15

[4]
How Does Epstein-Barr Virus Interact With Other Microbiomes in EBV-Driven Cancers?

Front Cell Infect Microbiol. 2022

[5]
Epstein Barr Virus: Development of Vaccines and Immune Cell Therapy for EBV-Associated Diseases.

Front Immunol. 2021

[6]
EBNA1-targeted inhibitors: Novel approaches for the treatment of Epstein-Barr virus-associated cancers.

Theranostics. 2018-10-22

[7]
Ferroptosis and Traditional Chinese Medicine for Type 2 Diabetes Mellitus.

Diabetes Metab Syndr Obes. 2023-6-26

[8]
Epstein-Barr Virus-Induced Epigenetic Pathogenesis of Viral-Associated Lymphoepithelioma-Like Carcinomas and Natural Killer/T-Cell Lymphomas.

Pathogens. 2018-7-18

[9]
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.

J Zhejiang Univ Sci B. 2013-1

[10]
Emerging Potential Therapeutic Targets of Ferroptosis in Skeletal Diseases.

Oxid Med Cell Longev. 2022

引用本文的文献

[1]
The critical role of ferroptosis in virus-associated hematologic malignancies and its potential value in antiviral-antitumor therapy.

Virulence. 2025-12

[2]
The relationship between ferroptosis and respiratory infectious diseases: a novel landscape for therapeutic approach.

Front Immunol. 2025-3-18

[3]
Ferroptosis-Related Gene Signatures: Prognostic Role in HPV-Positive Oropharyngeal Squamous Cell Carcinoma.

Cancers (Basel). 2025-2-5

本文引用的文献

[1]
Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest.

Cell Chem Biol. 2024-2-15

[2]
Isoquercitrin promotes ferroptosis and oxidative stress in nasopharyngeal carcinoma via the AMPK/NF-κB pathway.

J Biochem Mol Toxicol. 2024-1

[3]
Quercetin and Ferroptosis.

Life (Basel). 2023-8-11

[4]
FSP1: a key regulator of ferroptosis.

Trends Mol Med. 2023-9

[5]
BRD4 inhibition sensitizes diffuse large B-cell lymphoma cells to ferroptosis.

Blood. 2023-9-28

[6]
Specific regulation of BACH1 by the hotspot mutant p53 reveals a distinct gain-of-function mechanism.

Nat Cancer. 2023-4

[7]
Iron oxide nanoparticles inhibit tumor growth by ferroptosis in diffuse large B-cell lymphoma.

Am J Cancer Res. 2023-2-15

[8]
The interplay of oncogenic signaling, oxidative stress and ferroptosis in cancer.

Int J Cancer. 2023-9-1

[9]
The ferroptosis signature predicts the prognosis and immune microenvironment of nasopharyngeal carcinoma.

Sci Rep. 2023-2-2

[10]
Overcoming cancer chemotherapy resistance by the induction of ferroptosis.

Drug Resist Updat. 2023-1

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