Abutayeh Reem Fawaz, Altah Maram, Mehdawi Amani, Al-Ataby Israa, Ardakani Adel
Faculty of Pharmacy, Applied Science Private University, Amman 11937, Jordan.
School of Pharmacy, Al-Qadisiyah College, Amman 11118, Jordan.
Curr Issues Mol Biol. 2024 Jun 27;46(7):6600-6619. doi: 10.3390/cimb46070393.
Cancer, a major challenge to global health and healthcare systems, requires the study of alternative and supportive treatments due to the limitations of conventional therapies. This review examines the chemopreventive potential of three natural compounds: rosmarinic acid, apigenin, and thymoquinone. Derived from various plants, these compounds have demonstrated promising chemopreventive properties in in vitro, in vivo, and in silico studies. Specifically, they have been shown to inhibit cancer cell growth, induce apoptosis, and modulate key signaling pathways involved in cancer progression. The aim of this review is to provide a comprehensive overview of the current research on these phytochemicals, elucidating their mechanisms of action, therapeutic efficacy, and potential as adjuncts to traditional cancer therapies. This information serves as a valuable resource for researchers and healthcare providers interested in expanding their knowledge within the field of alternative cancer therapies.
癌症是全球健康和医疗保健系统面临的重大挑战，由于传统疗法存在局限性，因此需要研究替代疗法和支持性疗法。本综述探讨了三种天然化合物——迷迭香酸、芹菜素和百里醌的化学预防潜力。这些化合物源自多种植物，在体外、体内和计算机模拟研究中均显示出有前景的化学预防特性。具体而言，它们已被证明可抑制癌细胞生长、诱导细胞凋亡，并调节参与癌症进展的关键信号通路。本综述的目的是全面概述目前关于这些植物化学物质的研究，阐明其作用机制、治疗效果以及作为传统癌症疗法辅助手段的潜力。这些信息为有兴趣在替代癌症疗法领域拓展知识的研究人员和医疗服务提供者提供了宝贵资源。
