Department of Pharmacology, University of Granada, 18016 Granada, Spain.
Institute of Neuroscience, Biomedical Research Center, University of Granada, 18016 Granada, Spain.
Mar Drugs. 2024 Jun 24;22(7):290. doi: 10.3390/md22070290.
Fucoidan is a polymer of L-fucose and L-fucose-4-sulphate naturally found in marine sources that inhibits p-selectin, preventing neutrophil recruitment to the site of injury. Fucoidan is employed in many studies as a tool to investigate the contribution of neutrophils to pain, showing analgesic effects. We performed a systematic review and meta-analysis to quantify the analgesic effects of pretreatment with fucoidan reported in the available preclinical studies. In addition, we summarized the articles which have studied the therapeutic effects of fucoidan in pathological pain at preclinical and clinical levels. The results of this systematic review reveal that pretreatment with fucoidan is a powerful tool which reduces neutrophil infiltration by 70-90% at early time points. This meta-analysis showed that preventative treatment with fucoidan produced a significant pain reduction. In addition, several preclinical studies have observed that fucoidan treatment reduces the pain that is associated with various pathologies. Finally, fucoidan has also been tested in several clinical trials, with some degree of analgesic efficacy, but they were mostly small pilot studies. Considering all the above information, it can be concluded that fucoidan is not only a preclinical tool for studying the role of neutrophils in pain but also a promising therapeutic strategy for pain treatment.
岩藻聚糖是一种天然存在于海洋来源物中的 L-岩藻糖和 L-岩藻糖-4-硫酸盐的聚合物，可抑制 P-选择素，防止中性粒细胞募集到损伤部位。岩藻聚糖被广泛应用于许多研究中，作为一种研究中性粒细胞对疼痛贡献的工具，显示出镇痛作用。我们进行了系统评价和荟萃分析，以量化现有临床前研究中报告的岩藻聚糖预处理的镇痛效果。此外，我们总结了研究岩藻聚糖在临床前和临床水平病理性疼痛的治疗作用的文章。本系统评价的结果表明，岩藻聚糖预处理是一种强大的工具，可在早期将中性粒细胞浸润减少 70-90%。荟萃分析表明，预防性应用岩藻聚糖可显著减轻疼痛。此外，一些临床前研究观察到岩藻聚糖治疗可减轻与各种病理相关的疼痛。最后，岩藻聚糖也在几项临床试验中进行了测试，具有一定程度的镇痛疗效，但它们大多是小规模的初步研究。综上所述，岩藻聚糖不仅是研究中性粒细胞在疼痛中的作用的临床前工具，也是一种有前途的疼痛治疗策略。
