Universidad Estatal Amazónica, 160101 Puyo, Ecuador.
Departamento de Química Orgánica, Facultad de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Mar Drugs. 2024 Jul 22;22(7):327. doi: 10.3390/md22070327.
The marine kingdom is an important source of a huge variety of scaffolds inspiring the design of new drugs. The complex molecules found in the oceans present a great challenge to organic and medicinal chemists. However, the wide variety of biological activities they can display is worth the effort. In this article, we present an overview of different seaweeds as potential sources of bioactive pigments with activity against neurodegenerative diseases, especially due to their neuroprotective effects. Along with a broad introduction to seaweed as a source of bioactive pigments, this review is especially focused on astaxanthin and fucoxanthin as potential neuroprotective and/or anti-neurodegenerative agents. PubMed and SciFinder were used as the main sources to search and select the most relevant scientific articles within the field.
海洋生物王国是一个拥有丰富多样的支架的重要来源，这些支架为新药的设计提供了灵感。海洋中发现的复杂分子对有机和药物化学家来说是一个巨大的挑战。然而，它们能够表现出的广泛的生物活性是值得努力的。在本文中，我们概述了不同海藻作为生物活性色素的潜在来源，这些色素具有对抗神经退行性疾病的活性，特别是由于它们的神经保护作用。除了广泛介绍海藻作为生物活性色素的来源外，本综述特别关注虾青素和褐藻黄素作为潜在的神经保护和/或抗神经退行性药物。我们使用 PubMed 和 SciFinder 作为主要来源，在该领域内搜索和选择最相关的科学文章。
