Ellouze Ines, Korlagunta Kiranmayi, Lucas Edralin A, Payton Mark, Singar Saiful, Arjmandi Bahram H
Functional Physiology and Bio-Resources Valorization Laboratory, Higher Institute of Biotechnology of Beja, Jendouba University, Beja 9000, Tunisia.
Vijayavahini Charitable Foundation, Vijayawada 520008, Andhra Pradesh, India.
Healthcare (Basel). 2024 Jul 11;12(14):1392. doi: 10.3390/healthcare12141392.
Glucose control in postmenopausal women is influenced by many factors, such as hormones, lifestyle variables, and genetics. Limited data exist on the effect of whole flaxseed on glucose status in postmenopausal Native American women. The aim of this study was to investigate the glucose management effect of a flaxseed dietary intervention on postmenopausal Native American women. In this study, 55 Native American postmenopausal women (aged 47-63 years) with borderline hyperglycemia (>100 and <126 mg/dL) and mild to moderate hypercholestorolemia (≥200 to ≤380 mmol/L), who were not on hormone replacement therapy, were enrolled. Participants were randomly assigned to one of the three dietary regimens (control, flaxseed, and flaxseed + fiber) for three months, receiving interventions in the form of bread, muffins, and flaxseed powder. Despite daily consumption of flaxseed across diverse food formats, no significant changes in glucose ( = 0.3, = 0.2), insulin levels ( = 0.59, = 0.9), or HOMA-IR ( = 0.84, = 0.66) were observed compared to their respective baseline values within the flaxseed and flaxseed + fiber groups, respectively. Conversely, the control group showed a significant rise in final glucose values from baseline ( = 0.01). However, the incorporation of ground flaxseed into low-glycemic foods holds potential for beneficial effects through maintaining glucose status among postmenopausal Native American women. This research provides critical insights into the effects of flaxseed, emphasizing the need for continued exploration to understand its role in supporting glucose management among postmenopausal Native American women. Further exploration is required to investigate the potential long-term impact and the use of flaxseed in managing glucose levels in this demographic.
绝经后女性的血糖控制受多种因素影响，如激素、生活方式变量和遗传因素。关于全亚麻籽对绝经后美国原住民女性血糖状况影响的数据有限。本研究的目的是调查亚麻籽饮食干预对绝经后美国原住民女性血糖管理的效果。在本研究中，纳入了55名未接受激素替代疗法、患有临界高血糖（>100且<126mg/dL）和轻度至中度高胆固醇血症（≥200至≤380mmol/L）的美国原住民绝经后女性（年龄47 - 63岁）。参与者被随机分配到三种饮食方案（对照组、亚麻籽组和亚麻籽+纤维组）之一，为期三个月，接受面包、松饼和亚麻籽粉形式的干预。尽管每天食用多种形式的亚麻籽，但与亚麻籽组和亚麻籽+纤维组各自的基线值相比，未观察到血糖（P = 0.3，CI = 0.2）、胰岛素水平（P = 0.59，CI = 0.9）或HOMA-IR（P = 0.84，CI = 0.66）有显著变化。相反，对照组的最终血糖值较基线有显著升高（P = 0.01）。然而，将磨碎的亚麻籽加入低血糖食物中，有可能通过维持绝经后美国原住民女性的血糖状况而产生有益效果。本研究为亚麻籽的作用提供了关键见解，强调需要持续探索以了解其在支持绝经后美国原住民女性血糖管理中的作用。需要进一步探索以研究其潜在的长期影响以及亚麻籽在该人群中管理血糖水平的用途。
