Department of Health Technology, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.
MR Research Centre, Aarhus University, DK-8200 Aarhus, Denmark.
Tomography. 2024 Jul 13;10(7):1113-1122. doi: 10.3390/tomography10070084.
Water freely diffuses across cell membranes, making it suitable for measuring absolute tissue perfusion. In this study, we introduce an imaging method for conducting coronary artery angiography and quantifying myocardial perfusion across the entire heart using hyperpolarized water. H was hyperpolarized using dissolution dynamic nuclear polarization (dDNP) with UV-generated radicals. Submillimeter resolution coronary artery images were acquired as 2D projections using a spoiled GRE (SPGRE) sequence gated on diastole. Dynamic perfusion images were obtained with a multi-slice SPGRE with diastole gating, covering the entire heart. Perfusion values were analyzed through histograms, and the most frequent estimated perfusion value (the mode of the distribution), was compared with the average values for O water PET from the literature. A liquid state polarization of 10% at the time of the injection and a 30 s in DO TRIS buffer were measured. Both coronary artery and dynamic perfusion images exhibited good quality. The main and small coronary artery branches were well resolved. The most frequent estimated perfusion value is around 0.6 mL/g/min, which is lower than the average values obtained from the literature for O-water PET (around 1.1 and 1.5 mL/g/min). The study successfully demonstrated the feasibility of achieving high-resolution, motion-free coronary artery angiography and 3D whole-heart quantitative myocardial perfusion using hyperpolarized water.
水可以自由扩散穿过细胞膜，因此非常适合用于测量组织的绝对灌注量。在这项研究中，我们介绍了一种使用超极化水进行冠状动脉造影和量化整个心脏心肌灌注的成像方法。H 通过使用紫外线产生的自由基进行溶解动态核极化（dDNP）进行超极化。使用在舒张期门控的扰相 GRE（SPGRE）序列获得亚毫米分辨率的冠状动脉图像作为 2D 投影。使用具有舒张期门控的多切片 SPGRE 获得动态灌注图像，覆盖整个心脏。通过直方图分析灌注值，并将最频繁的估计灌注值（分布的模式）与文献中 O 水 PET 的平均灌注值进行比较。在注射时测量到 10%的液体状态极化和 30 秒的 DO TRIS 缓冲时间。冠状动脉和动态灌注图像均显示出良好的质量。主要和小冠状动脉分支得到了很好的分辨。最频繁的估计灌注值约为 0.6 毫升/克/分钟，低于文献中 O 水 PET 的平均灌注值（约 1.1 和 1.5 毫升/克/分钟）。该研究成功地证明了使用超极化水实现高分辨率、无运动的冠状动脉造影和 3D 全心脏定量心肌灌注的可行性。
