通过紫外线产生的自由基进行溶解动态核极化的超极化水。
Hyperpolarized water through dissolution dynamic nuclear polarization with UV-generated radicals.
作者信息
Pinon Arthur C, Capozzi Andrea, Ardenkjær-Larsen Jan Henrik
机构信息
Center for Hyperpolarization in Magnetic Resonance, Department of Health Technology, Technical University of Denmark, Building 349, 2800, Kgs Lyngby, Denmark.
出版信息
Commun Chem. 2020 May 8;3(1):57. doi: 10.1038/s42004-020-0301-6.
In recent years, hyperpolarization of water protons via dissolution Dynamic Nuclear Polarization (dDNP) has attracted increasing interest in the magnetic resonance community. Hyperpolarized water may provide an alternative to Gd-based contrast agents for angiographic and perfusion Magnetic Resonance Imaging (MRI) examinations, and it may report on chemical and biochemical reactions and proton exchange while perfoming Nuclear Magnetic Resonance (NMR) investigations. However, hyperpolarizing water protons is challenging. The main reason is the presence of radicals, required to create the hyperpolarized nuclear spin state. Indeed, the radicals will also be the main source of relaxation during the dissolution and transfer to the NMR or MRI system. In this work, we report water magnetizations otherwise requiring a field of 10,000 T at room temperature on a sample of pure water, by employing dDNP via UV-generated, labile radicals. We demonstrate the potential of our methodology by acquiring a N spectrum from natural abundance urea with a single scan, after spontaneous magnetization transfer from water protons to nitrogen nuclei.
近年来,通过溶解动态核极化(dDNP)实现水质子的超极化在磁共振领域引起了越来越多的关注。超极化水可能为基于钆的造影剂提供替代方案,用于血管造影和灌注磁共振成像(MRI)检查,并且在进行核磁共振(NMR)研究时,它可以报告化学和生化反应以及质子交换情况。然而,使水质子超极化具有挑战性。主要原因是存在用于创建超极化核自旋态所需的自由基。实际上,这些自由基也将是溶解过程以及转移到NMR或MRI系统期间弛豫的主要来源。在这项工作中,我们通过利用紫外线产生的不稳定自由基进行dDNP,在纯水样品上实现了在室温下原本需要10000 T磁场才能实现的水磁化强度。通过在水质子自发磁化转移到氮核后单次扫描获取天然丰度尿素的N谱,我们展示了我们方法的潜力。
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