College of Life Science, Jiang Han University, Wuhan, 430056, China.
State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
Small. 2024 Sep;20(36):e2402980. doi: 10.1002/smll.202402980. Epub 2024 Jul 26.
Virus-like particles (VLPs) are nanostructures composed of one or more structural proteins, exhibiting stable and symmetrical structures. Their precise compositions and dimensions provide versatile opportunities for modifications, enhancing their functionality. Consequently, VLP-based nanomaterials have gained widespread adoption across diverse domains. This review focuses on three key aspects: the mechanisms of viral capsid protein self-assembly into VLPs, design methods for constructing multifunctional VLPs, and strategies for synthesizing multidimensional nanomaterials using VLPs. It provides a comprehensive overview of the advancements in virus-inspired functional nanomaterials, encompassing VLP assembly, functionalization, and the synthesis of multidimensional nanomaterials. Additionally, this review explores future directions, opportunities, and challenges in the field of VLP-based nanomaterials, aiming to shed light on potential advancements and prospects in this exciting area of research.
病毒样颗粒(VLPs)是由一种或多种结构蛋白组成的纳米结构,具有稳定和对称的结构。其精确的组成和尺寸为修饰提供了多种机会,增强了它们的功能。因此,基于 VLP 的纳米材料在各个领域得到了广泛的应用。本综述重点关注三个关键方面:病毒衣壳蛋白自我组装成 VLPs 的机制、构建多功能 VLPs 的设计方法,以及使用 VLPs 合成多维纳米材料的策略。它全面概述了受病毒启发的功能纳米材料的进展,包括 VLP 的组装、功能化和多维纳米材料的合成。此外,本综述还探讨了基于 VLP 的纳米材料领域的未来方向、机遇和挑战,旨在为该研究领域的潜在进展和前景提供启示。