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- 过去、现在与未来。

-Past, Present and Future.

作者信息

Toc Dan Alexandru, Costache Carmen, Neculicioiu Vlad Sever, Rusu Irina-Maria, Roznovan Bogdan-Valentin, Botan Alexandru, Toc Adelina Georgiana, Șchiopu Pavel, Panaitescu Paul-Stefan, Pană Adrian Gabriel, Colosi Ioana Alina

机构信息

Department of Microbiology, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.

Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.

出版信息

Antibiotics (Basel). 2024 Jun 26;13(7):589. doi: 10.3390/antibiotics13070589.

Abstract

is a Gram-negative rod part of the family (order ) and a rare cause of human infections. Although improved diagnostic methods have led to an increase in reports of this elusive pathogen, information remains limited. In order to provide a better understanding of this bacterium, we developed the first comprehensive review of its biology, biochemical profile, antimicrobial resistance pattern, virulence factors, natural reservoir and involvement in various veterinary and human infections. Human infections with this bacterium are scarcely reported, most probably due to constraints regarding its identification and biochemical similarities to . Multiple systematic searches revealed 23 cases of human infection, with a seemingly worldwide distribution, mostly in middle-aged or elderly male patients, often associated with immunosuppression. To date, has been reported in skin and soft tissue infections, bacteremia and sepsis, osteoarticular infections and in others such as urinary tract and digestive infections. The unique ability of to degrade polystyrene presents a novel and promising avenue for addressing plastic pollution in the near future. However, large-scale applications of this bacterium will undoubtedly increase human exposure, highlighting the necessity for comprehensive research into its role in human and veterinary infections, pathogenicity and antibiotic resistance.

摘要

是革兰氏阴性杆菌,属于(目)科,是人类感染的罕见病因。尽管改进的诊断方法导致这种难以捉摸的病原体报告有所增加,但相关信息仍然有限。为了更好地了解这种细菌,我们对其生物学、生化特征、抗菌耐药模式、毒力因子、天然宿主以及在各种兽医和人类感染中的情况进行了首次全面综述。人类感染这种细菌的报告很少,很可能是由于其鉴定方面的限制以及与的生化相似性。多次系统检索发现23例人类感染病例,分布似乎遍及全球,大多为中年或老年男性患者,常与免疫抑制有关。迄今为止,已在皮肤和软组织感染、菌血症和败血症、骨关节炎感染以及其他如尿路感染和消化道感染中被报道。降解聚苯乙烯的独特能力为在不久的将来解决塑料污染提供了一条新颖且有前景的途径。然而,这种细菌的大规模应用无疑会增加人类接触,凸显了对其在人类和兽医感染中的作用、致病性和抗生素耐药性进行全面研究的必要性。

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本文引用的文献

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