Crowe P J, Dennison A R, Royle G T
JPEN J Parenter Enteral Nutr. 1985 Nov-Dec;9(6):720-4. doi: 10.1177/0148607185009006720.
The effects of carbohydrate, lipid, and nitrogen metabolism of recently available lipid emulsions containing either 50% medium-chain triglyceride (MCT) and 50% long-chain triglyceride (LCT) or 100% LCT were compared in elective surgical patients. Postoperative urinary urea excretion was similar during isocaloric MCT/LCT and LCT infusions (1.9 mg/kg/min) and was decreased compared with a standard infusion of 5% glucose (1 mg/kg/min). Plasma glucose and insulin concentrations were similar during both lipid and low dose glucose infusions. However, plasma triglyceride and nonesterified fatty acid concentrations were decreased during the MCT/LCT infusion compared with the LCT infusion, suggesting that the MCT/LCT emulsion was cleared from the circulation faster than pure LCT. Ketone body concentrations were similar during all three infusions. MCT/LCT emulsion can be safely infused perioperatively and has similar nitrogen conserving properties to LCT in these circumstances.
在择期手术患者中，比较了含有50%中链甘油三酯（MCT）和50%长链甘油三酯（LCT）或100%LCT的近期可用脂质乳剂对碳水化合物、脂质和氮代谢的影响。在等热量的MCT/LCT和LCT输注（1.9毫克/千克/分钟）期间，术后尿尿素排泄相似，与标准的5%葡萄糖输注（1毫克/千克/分钟）相比有所降低。在脂质和低剂量葡萄糖输注期间，血浆葡萄糖和胰岛素浓度相似。然而，与LCT输注相比，MCT/LCT输注期间血浆甘油三酯和非酯化脂肪酸浓度降低，这表明MCT/LCT乳剂从循环中清除的速度比纯LCT快。在所有三种输注期间，酮体浓度相似。在这些情况下，MCT/LCT乳剂可在围手术期安全输注，并且在氮保留特性方面与LCT相似。
