Mascioli E A, Lopes S, Randall S, Porter K A, Kater G, Hirschberg Y, Babayan V K, Bistrian B R, Blackburn G L
Department of Medicine, Harvard Medical School, New England Deaconess Hospital, Boston, MA.
Lipids. 1989 Sep;24(9):793-8. doi: 10.1007/BF02544586.
The serum fatty acid profiles of patients receiving either intravenous medium or long chain triglycerides were studied. Seventeen hospitalized patients, dependent on total parenteral nutrition, were randomly enrolled into a prospective study. The total parenteral nutrition (TPN) delivered amino acids and glucose and either a 75% medium chain triglyceride and 25% long chain triglyceride (MCT group) physical mixture or all long chain triglyceride (LCT group), as the respective fat sources. The amino acids and glucose were given continuously, and the lipid was given for 10 hours each day over five days. Fatty acid profiles on serum triglycerides and free fatty acids were done in the morning before any lipid was given and also later in the afternoon, near the end of the lipid administration, on days 1, 3 and 5. Medium chain fatty acids rose quickly in the triglyceride fraction in patients given MCT. Rapid MCT hydrolysis occurred as evidenced by the appearance of medium chain fatty acids in the free fatty acid fraction in the afternoon sampling. Clearance of the hydrolyzed medium chain free fatty acids (MCFFA) occurred so that little, if any, were present in the morning sampling one day later. Long chain fatty acids, as either triglycerides or free fatty acids, showed expected increases during the daily infusion, but not of such relative magnitude as the medium chain fatty acids. Medium chain fatty acid incorporation into the phospholipid or cholesterol ester fractions by the end of the five-day feeding period was present but minimal.(ABSTRACT TRUNCATED AT 250 WORDS)
对接受静脉输注中链或长链甘油三酯的患者的血清脂肪酸谱进行了研究。17名依赖全胃肠外营养的住院患者被随机纳入一项前瞻性研究。全胃肠外营养（TPN）提供氨基酸、葡萄糖，并分别以75%中链甘油三酯和25%长链甘油三酯的物理混合物（MCT组）或全为长链甘油三酯（LCT组）作为脂肪来源。氨基酸和葡萄糖持续输注，脂质在五天内每天输注10小时。在第1、3和5天，于早晨在给予任何脂质之前以及下午接近脂质输注结束时，对血清甘油三酯和游离脂肪酸的脂肪酸谱进行检测。给予MCT的患者中，中链脂肪酸在甘油三酯部分迅速升高。快速的MCT水解发生，下午采样时游离脂肪酸部分出现中链脂肪酸即为证据。水解的中链游离脂肪酸（MCFFA）被清除，以至于在一天后的早晨采样中几乎没有（如果有的话）。长链脂肪酸，无论是作为甘油三酯还是游离脂肪酸，在每日输注期间均出现预期的升高，但幅度不如中链脂肪酸。在为期五天的喂养期结束时，中链脂肪酸掺入磷脂或胆固醇酯部分，但量极少。（摘要截短于250字）
