Iriyama K, Miki C, Inoue T, Kawarabayashi N, Urata H, Shigemori C
Second Department of Surgery, Mie University School of Medicine, Edobashi, Tsu, Japan.
Surg Today. 1998;28(3):289-92. doi: 10.1007/s005950050123.
As medium-chain triglyceride emulsions (MCT) are more rapidly hydrolyzed than long-chain triglyceride emulsions (LCT), MCT/LCT tends to be infused faster than LCT. The purpose of the present study was to determine the most appropriate infusion rate for MCT/LCT to stabilize plasma concentrations of triglyceride (TG), being equivalent to the optimal infusion rate of the emulsion. A TG clamp was set up by raising the mean +/- SD concentrations of TG in plasma, being 1.08 +/- 0.18 delta mmol l(-1) for LCT, and 1.65 +/- 0.31 delta mmol l(-1) for MCT/LCT after a 50-min priming infusion of each emulsion. Thereafter, the infusion rate of lipid was controlled every 10 min to maintain a steady concentration of TG for a period of 150 min. A constant infusion of glucose at 0.32 g/kg body weight (BW) per h was administered for the test period. The weight-based rate of the infusion to maintain a steady state of plasma TG concentrations did not differ between MCT/LCT and LCT, being 0.125 +/- 0.013 vs 0.117 +/- 0.021 g/kg BW per h, while the molar-based infusion rate was 0.203 +/- 0.021 mmol/kg BW per h for MCT/LCT and 0.132 +/- 0.023 mmol/kg BW per h for LCT (P < 0.05). These results suggest that although 54% more molar MCT/LCT-TG can be hydrolyzed during a constant infusion, MCT/LCT should not be infused at a rate faster than 0.1 g/kg BW per h under a steady state.
由于中链甘油三酯乳剂（MCT）比长链甘油三酯乳剂（LCT）水解更快，MCT/LCT往往比LCT输注速度更快。本研究的目的是确定MCT/LCT的最合适输注速率，以稳定甘油三酯（TG）的血浆浓度，等同于乳剂的最佳输注速率。通过提高血浆中TG的平均±标准差浓度来建立TG钳夹，在每种乳剂进行50分钟的初始输注后，LCT的血浆TG浓度为1.08±0.18Δmmol l⁻¹，MCT/LCT为1.65±0.31Δmmol l⁻¹。此后，每10分钟控制一次脂质输注速率，以在150分钟内维持TG的稳定浓度。在测试期间，以每小时0.32 g/kg体重（BW）的速率持续输注葡萄糖。维持血浆TG浓度稳定状态的基于体重的输注速率在MCT/LCT和LCT之间没有差异，分别为0.125±0.013和0.117±0.021 g/kg BW每小时，而基于摩尔的输注速率，MCT/LCT为0.203±0.021 mmol/kg BW每小时，LCT为0.132±0.023 mmol/kg BW每小时（P<0.05）。这些结果表明，尽管在持续输注期间，MCT/LCT-TG的摩尔量可多水解54%，但在稳态下，MCT/LCT的输注速率不应超过0.1 g/kg BW每小时。
