Mognetti Barbara, Franco Francesco, Castrignano Chiara, Bovolin Patrizia, Berta Giovanni Nicolao
Department of Life Sciences and Systems Biology, University of Turin, Via Accademia Albertina 13, 10123 Turin, Italy.
Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Orbassano, Italy.
Antioxidants (Basel). 2024 Jun 27;13(7):782. doi: 10.3390/antiox13070782.
Cadmium (Cd) toxicity poses a significant threat to human health and the environment due to its widespread occurrence and persistence. In recent years, considerable attention has been directed towards exploring natural compounds with potential protective effects against Cd-induced toxicity. Among these compounds, resveratrol (RV) has emerged as a promising candidate, demonstrating a range of beneficial effects attributed to its antioxidant and anti-inflammatory properties. This literature review systematically evaluates the protective role of RV against Cd toxicity, considering the various mechanisms of action involved. A comprehensive analysis of both in vitro and in vivo studies is conducted to provide a comprehensive understanding of RV efficacy in mitigating Cd-induced damage. Additionally, this review highlights the importance of phytoremediation strategies in addressing Cd contamination, emphasizing the potential of RV in enhancing the efficiency of such remediation techniques. Through the integration of diverse research findings, this review underscores the therapeutic potential of RV in combating Cd toxicity and underscores the need for further investigation to elucidate its precise mechanisms of action and optimize its application in environmental and clinical settings.
镉（Cd）毒性因其广泛存在和持久性，对人类健康和环境构成重大威胁。近年来，人们相当关注探索对镉诱导的毒性具有潜在保护作用的天然化合物。在这些化合物中，白藜芦醇（RV）已成为一个有前景的候选物，因其抗氧化和抗炎特性展现出一系列有益效果。这篇文献综述系统地评估了白藜芦醇对镉毒性的保护作用，考虑到所涉及的各种作用机制。对体外和体内研究进行了全面分析，以全面了解白藜芦醇在减轻镉诱导损伤方面的功效。此外，本综述强调了植物修复策略在解决镉污染方面的重要性，强调了白藜芦醇在提高此类修复技术效率方面的潜力。通过整合不同的研究结果，本综述强调了白藜芦醇在对抗镉毒性方面的治疗潜力，并强调需要进一步研究以阐明其确切作用机制，并优化其在环境和临床环境中的应用。
