Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, 70-111 Szczecin, Poland.
Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 70-111 Szczecin, Poland.
Genes (Basel). 2024 Jul 2;15(7):871. doi: 10.3390/genes15070871.
Acute coronary heart disease (CHD) is mainly caused by the rupture of an unstable atherosclerotic plaque. Many different factors can cause stenosis or even occlusion of the coronary artery lumen, such as vasculitis and platelet aggregation. Our study was performed to assess the association between rs662, rs854560 and rs17321515, rs2954029 polymorphisms and the risk of CHD, as well as the association between studied polymorphisms and selected clinical parameters affecting the risk of developing ischemic heart disease. A total of 232 patients with unstable angina were enrolled in this study. There were no statistically significant differences in the rs662, rs854560 and rs17321515, rs2954029 polymorphism distributions between the total study and control groups. Total cholesterol plasma levels were significantly higher in patients with the rs662 TT genotype compared to those with the CC+TC genotypes, as well as in patients with the rs854560 TT genotype compared to those with the AA+AT genotypes. LDL plasma levels were significantly increased in patients with the rs854560 TT genotype compared to those with the AA+AT genotypes. Plasma levels of HDL were significantly decreased in patients with the rs17321515 AA+AG genotypes compared to those with the GG genotype, as well as in patients with the rs2954029 AA+AT genotypes compared to those with the TT genotype. Our results suggest that the analysed polymorphisms are not risk factors for unstable angina in the Polish population. However, the results of this study indicate an association between the rs662, rs854560 and rs17321515, rs2954029 polymorphisms with lipid parameters in patients with coronary artery disease.
急性冠状动脉心脏病（CHD）主要是由不稳定的动脉粥样硬化斑块破裂引起的。许多不同的因素可导致冠状动脉腔的狭窄甚至闭塞，如血管炎和血小板聚集。我们的研究旨在评估 rs662、rs854560 和 rs17321515、rs2954029 多态性与 CHD 风险之间的关系，以及研究多态性与影响缺血性心脏病发生风险的选定临床参数之间的关系。本研究共纳入 232 例不稳定型心绞痛患者。在总研究组和对照组之间，rs662、rs854560 和 rs17321515、rs2954029 多态性分布无统计学差异。与 CC+TC 基因型相比，rs662 TT 基因型患者的总胆固醇血浆水平明显升高，与 AA+AT 基因型相比，rs854560 TT 基因型患者的总胆固醇血浆水平明显升高。与 AA+AT 基因型相比，rs854560 TT 基因型患者的 LDL 血浆水平明显升高。与 GG 基因型相比，rs17321515 AA+AG 基因型患者的 HDL 血浆水平明显降低，与 TT 基因型相比，rs2954029 AA+AT 基因型患者的 HDL 血浆水平明显降低。我们的结果表明，在波兰人群中，分析的多态性不是不稳定型心绞痛的危险因素。然而，本研究的结果表明，rs662、rs854560 和 rs17321515、rs2954029 多态性与冠心病患者的脂质参数之间存在关联。
