Lagrange Emmeline, Vernoux Jean-Paul, Chambon Celia, Camu William, Spencer Peter S
Department of Neurology, Reference Center of Neuromuscular Disease and ALS Consultations, Grenoble University Hospital, 38043 Grenoble, France.
Unité de Recherche Aliments Bioprocédés Toxicologie Environnements (ABTE) EA 4651, Normandie University, UNICAEN, 14000 Caen, France.
Foods. 2024 Jul 17;13(14):2257. doi: 10.3390/foods13142257.
Cramp-fasciculation syndrome (CFS) is a rare and benign neuromuscular disorder that may initially masquerade as motor neuron disease/amyotrophic lateral sclerosis. While CFS may have a familial disposition, we report on cases associated with high consumption of popular food items. One set of patients reversibly experienced acute onset of headache, flushing, muscle stiffness and fasciculations following the consumption of umami-flavored food containing a large concentration of monosodium glutamate. A second group of patients consuming food derived from lupin seed developed acute cholinergic toxicity, CFS, and, with chronic intake, significant, self-limiting, but incompletely reversible upper and lower motor neuron deficits. While these cases may improve our knowledge about the possible causes of CFS, our series also demonstrates that excessive consumption of some popular foods is not harmless. This warrants further research on their safety at all stages of human development from a neurological point of view.
痛性肌束震颤综合征（CFS）是一种罕见的良性神经肌肉疾病，最初可能伪装成运动神经元病/肌萎缩侧索硬化症。虽然CFS可能有家族倾向，但我们报告了与大量食用流行食品相关的病例。一组患者在食用含有高浓度味精的鲜味食品后，可逆地出现急性头痛、脸红、肌肉僵硬和肌束震颤。第二组食用羽扇豆种子衍生食品的患者出现急性胆碱能毒性、CFS，长期摄入后出现明显的、自限性但不完全可逆的上下运动神经元缺陷。虽然这些病例可能增进我们对CFS可能病因的了解，但我们的系列研究也表明，过量食用某些流行食品并非无害。从神经学角度来看，这值得对其在人类发育各个阶段的安全性进行进一步研究。
