Gromek Weronika, Kołdej Natalia, Świtała Szymon, Majsiak Emilia, Kurowski Marcin
Polish-Ukrainian Foundation of Medicine Development, Nałęczowska 14, 20-701 Lublin, Poland.
Department of Immunology and Allergy, Medical University of Lodz, 90-419 Lodz, Poland.
J Clin Med. 2024 Jul 19;13(14):4222. doi: 10.3390/jcm13144222.
Thirty years have passed since the concept of latex-fruit syndrome (LFS) was first introduced. Since then, this phenomenon, characterized by cross-reactivity between natural latex rubber allergens and certain fruit allergens, has been extensively studied. This literature review sought to determine the prevalence of LFS in latex-allergic patients, identify the most common cross-reactions with fruit allergens in individuals with LFS, and understand the clinical manifestations of this syndrome. An extensive literature search was carried out using PubMed and Scopus databases, while applying the Preferred Reporting Items for Systematic Reviews and Meta-Analysis methodology. The analysis of original studies revealed a wide variation in LFS prevalence (4-88%) influenced by diverse diagnostic tools, different geographical regions, and the size of study populations. Our findings indicate that the most prevalent allergenic fruits in patients with LFS are banana, avocado, kiwifruit, and papaya. After evaluating the symptoms of the fruit hypersensitivity of patients with LFS, the clinical manifestation of hypersensitivity constituted 73% of systemic allergy symptoms and only 27% of reported symptoms described the localized allergy. Furthermore, the clinical picture of latex-fruit syndrome is illustrated through two cases, one typical and one with an unusual presentation. Their clinical features were assessed and contrasted utilizing different anaphylaxis severity grading criteria. To properly manage LFS, it is essential to establish standardized diagnostic criteria and severity grading systems, as these are crucial for accurate diagnosis and effective treatment.
自首次提出乳胶 - 水果综合征（LFS）的概念以来，已经过去了三十年。从那时起，这种以天然乳胶橡胶过敏原与某些水果过敏原之间的交叉反应为特征的现象得到了广泛研究。这篇文献综述旨在确定乳胶过敏患者中LFS的患病率，识别LFS患者中与水果过敏原最常见的交叉反应，并了解该综合征的临床表现。使用PubMed和Scopus数据库进行了广泛的文献检索，同时应用系统评价和Meta分析的首选报告项目方法。对原始研究的分析表明，受不同诊断工具、不同地理区域和研究人群规模的影响，LFS患病率存在很大差异（4 - 88%）。我们的研究结果表明，LFS患者中最常见的致敏水果是香蕉、鳄梨、猕猴桃和木瓜。在评估LFS患者水果过敏的症状后，过敏的临床表现构成了73%的全身过敏症状，而报告症状中只有27%描述了局部过敏。此外，通过两个病例说明了乳胶 - 水果综合征的临床表现，一个典型病例和一个表现不寻常的病例。利用不同的过敏严重程度分级标准对它们的临床特征进行了评估和对比。为了妥善管理LFS，建立标准化的诊断标准和严重程度分级系统至关重要，因为这些对于准确诊断和有效治疗至关重要。
