Department of Cardiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, 55131 Mainz, Germany.
Nutrients. 2024 Jul 13;16(14):2265. doi: 10.3390/nu16142265.
The exposome concept includes nutrition as it significantly influences human health, impacting the onset and progression of diseases. Gluten-containing wheat products are an essential source of energy for the world's population. However, a rising number of non-celiac healthy individuals tend to reduce or completely avoid gluten-containing cereals for health reasons.
This prospective interventional human study aimed to investigate whether short-term gluten avoidance improves cardiovascular endpoints and quality of life (QoL) in healthy volunteers. A cohort of 27 participants followed a strict gluten-free diet (GFD) for four weeks. Endothelial function measured by flow-mediated vasodilation (FMD), blood testing, plasma proteomics (Olink) and QoL as measured by the World Health Organisation Quality-of-Life (WHOQOL) survey were investigated.
GFD resulted in decreased leucocyte count and C-reactive protein levels along with a trend of reduced inflammation biomarkers determined by plasma proteomics. A positive trend indicated improvement in FMD, whereas other cardiovascular endpoints remained unchanged. In addition, no improvement in QoL was observed.
In healthy individuals, a short-term GFD demonstrated anti-inflammatory effects but did not result in overall cardiovascular improvement or enhanced quality of life.
外核组学概念包含营养，因为它对人类健康有重大影响，影响疾病的发生和发展。含麸质的小麦产品是全球人口的重要能量来源。然而，越来越多的非乳糜泻健康个体出于健康原因倾向于减少或完全避免食用含麸质的谷物。
本前瞻性干预性人体研究旨在探讨短期无麸质饮食是否能改善健康志愿者的心血管终点和生活质量（QoL）。一组 27 名参与者遵循严格的无麸质饮食（GFD）四周。通过血流介导的血管扩张（FMD）、血液检测、血浆蛋白质组学（Olink）和世界卫生组织生活质量（WHOQOL）调查测量的生活质量来评估内皮功能、血液测试、血浆蛋白质组学（Olink）和生活质量。
GFD 导致白细胞计数和 C 反应蛋白水平降低，同时通过血浆蛋白质组学确定的炎症生物标志物呈下降趋势。FMD 呈阳性趋势，表明改善，而其他心血管终点保持不变。此外，生活质量没有改善。
在健康个体中，短期 GFD 显示出抗炎作用，但不会导致整体心血管改善或提高生活质量。
