Li Mei-Ye, Ye Wei, Luo Ke-Wang
School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
People's Hospital of Longhua, The affiliated hospital of Southern Medical University, Shenzhen 518109, China.
Pharmaceutics. 2024 Jun 27;16(7):865. doi: 10.3390/pharmaceutics16070865.
Tumor-associated macrophages (TAMs) are one of the most plentiful immune compositions in the tumor microenvironment, which are further divided into anti-tumor M1 subtype and pro-tumor M2 subtype. Recent findings found that TAMs play a vital function in the regulation and progression of tumorigenesis. Moreover, TAMs promote tumor vascularization, and support the survival of tumor cells, causing an impact on tumor growth and patient prognosis. Numerous studies show that reducing the density of TAMs, or modulating the polarization of TAMs, can inhibit tumor growth, indicating that TAMs are a promising target for tumor immunotherapy. Recently, clinical trials have found that treatments targeting TAMs have achieved encouraging results, and the U.S. Food and Drug Administration has approved a number of drugs for use in cancer treatment. In this review, we summarize the origin, polarization, and function of TAMs, and emphasize the therapeutic strategies targeting TAMs in cancer treatment in clinical studies and scientific research, which demonstrate a broad prospect of TAMs-targeted therapies in tumor immunotherapy.
肿瘤相关巨噬细胞（TAMs）是肿瘤微环境中最丰富的免疫成分之一，可进一步分为抗肿瘤M1亚型和促肿瘤M2亚型。最近的研究发现，TAMs在肿瘤发生的调控和进展中发挥着至关重要的作用。此外，TAMs促进肿瘤血管生成，并支持肿瘤细胞的存活，对肿瘤生长和患者预后产生影响。大量研究表明，降低TAMs的密度或调节TAMs的极化可抑制肿瘤生长，这表明TAMs是肿瘤免疫治疗的一个有前景的靶点。最近，临床试验发现针对TAMs的治疗取得了令人鼓舞的结果，美国食品药品监督管理局已批准多种药物用于癌症治疗。在这篇综述中，我们总结了TAMs的起源、极化和功能，并强调了临床研究和科学研究中针对TAMs的癌症治疗策略，这表明TAMs靶向治疗在肿瘤免疫治疗中具有广阔的前景。
