Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing 100191, PR China; Department of Biostatistics, School of Public Health, Peking University, Beijing 100191, PR China.
Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, PR China.
Autoimmun Rev. 2024 Nov;23(11):103655. doi: 10.1016/j.autrev.2024.103655. Epub 2024 Oct 2.
Inflammatory bowel disease (IBD) is a kind of chronic inflammatory disorders of the gastrointestinal tract with diverse prevalence rates and patterns globally. Accurate comprehension of the disease's epidemiological characteristics is imperative for disease control and prevention all over the world.
To provide the most updated estimates on the global burden of IBD using the 2019 Global Burden of Disease (GBD) study data, to systematically analyze the IBD epidemiological characteristics at the global, regional, and national levels including the prevalence, incidence, and disability-adjusted life years (DALY) rates, and to analyze the correlations of the socioeconomic development level with IBD epidemiological characteristics.
We conducted an overall analysis of the global, regional, and national burden of IBD from 1990 to 2019, data from the 2019 GBD study. The GBD's classification of the world into 21 regions and 204 countries and territories facilitated a thorough examination. Age-standardized estimated annual percentage changes (EAPCs) were computed to assess the temporal trends in IBD age-standardized rates (ASRs), with age standardization employed to mitigate potential confounding effects from age structure. The sociodemographic Index (SDI) was used to correlate the socioeconomic development level with the epidemiological characteristics of IBD.
From 1990 to 2019, the global age-standardized prevalence, incidence, and DALY rates of IBD remained high. There was a slight downward trend in the global age-standardized incidence and DALY rates of IBD and men exhibited higher DALY rates than women. In 2019, high-income North America recorded the highest age-standardized prevalence, incidence, and DALY rates, while Oceania had the lowest age-standardized prevalence and incidence rates. South Asia had the lowest age-standardized DALY rates. The age-standardized mortality and DALY rates decreased as SDI values increased and remained higher than the expected levels over the past three decades. A negative correlation was observed between age-standardized DALY rates and SDI at the national level.
This analysis of the GBD 2019 database demonstrates that the overall global burden of IBD is still high. Meanwhile, an increasing disease burden is observed in the middle and low SDI locations.
炎症性肠病（IBD）是一种全球范围内具有不同流行率和模式的慢性胃肠道炎症性疾病。准确理解疾病的流行病学特征对于全球范围内的疾病控制和预防至关重要。
利用 2019 年全球疾病负担（GBD）研究数据，提供 IBD 全球负担的最新估计值，系统分析全球、区域和国家各级 IBD 的流行病学特征，包括患病率、发病率和残疾调整生命年（DALY）率，并分析社会经济发展水平与 IBD 流行病学特征的相关性。
我们对 1990 年至 2019 年全球、区域和国家 IBD 负担进行了全面分析，数据来自 2019 年 GBD 研究。GBD 将世界划分为 21 个区域和 204 个国家和地区，便于进行全面分析。计算年龄标准化估计年百分比变化（EAPC），以评估 IBD 年龄标准化率（ASR）的时间趋势，采用年龄标准化以减轻年龄结构潜在的混杂影响。社会人口学指数（SDI）用于将社会经济发展水平与 IBD 的流行病学特征相关联。
1990 年至 2019 年，全球 IBD 的年龄标准化患病率、发病率和 DALY 率仍然很高。全球 IBD 的年龄标准化发病率和 DALY 率略有下降，男性的 DALY 率高于女性。2019 年，高收入的北美地区记录了最高的年龄标准化患病率、发病率和 DALY 率，而大洋洲的年龄标准化患病率和发病率最低。南亚的年龄标准化 DALY 率最低。随着 SDI 值的增加，年龄标准化死亡率和 DALY 率下降，但在过去三十年中仍高于预期水平。国家一级的年龄标准化 DALY 率与 SDI 呈负相关。
本研究对 GBD 2019 数据库的分析表明，IBD 的全球总体负担仍然很高。同时，中低 SDI 地区的疾病负担呈上升趋势。
