Dos Reis Lisiane Lappe, de Souza Lirna Salvioni Silva, Fonseca Fernanda Rodrigues, Nava Alessandra Ferreira Dales, Vicente Ana Carolina Paulo
Fundação Oswaldo Cruz-Fiocruz, Instituto Leônidas & Maria Deane, Laboratório de Diversidade Microbiana da Amazônia de Importância para a Saúde - DMAIS, Manaus, AM, Brazil.
Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Genética Molecular de Microrganismos - LGMM, Rio de Janeiro, RJ, Brazil.
One Health. 2024 Jul 4;19:100853. doi: 10.1016/j.onehlt.2024.100853. eCollection 2024 Dec.
Bats are important reservoirs and spreaders of pathogens. is a globally important protozoan that infects humans and other mammals with considerable public health burden, particularly on the child development. Based on genetic variation and host specificity, is categorized into eight genotypes/assemblages A-H. Assemblages A and B are widespread globally and are associated with human and animal disease. There is evidence of in the bat feces from diverse geographic regions, but the assemblages are unknown, which is a key point for the One Health view. Here, we successfully amplified the BG/GDH/DIS3/HCMP2/HCMP3 targets of from five bat species captured in the Brazilian Amazon biome revealing the presence of zoonotic assemblages A and B in the feces of these flying mammals. Our study reveals that bats may play a role in transmission of zoonotic , at least in this biome.
蝙蝠是病原体的重要宿主和传播者。[某种病原体名称]是一种全球重要的原生动物,会感染人类和其他哺乳动物,给公共卫生带来相当大的负担,尤其是对儿童发育。基于基因变异和宿主特异性,[某种病原体名称]被分为八个基因型/组合A - H。组合A和B在全球广泛分布,并与人类和动物疾病有关。有证据表明在来自不同地理区域的蝙蝠粪便中存在[某种病原体名称],但其组合情况未知,这是“同一健康”观点的关键要点。在这里,我们成功地从在巴西亚马逊生物群落捕获的五种蝙蝠物种中扩增出了[某种病原体名称]的BG/GDH/DIS3/HCMP2/HCMP3靶点,揭示了这些飞行哺乳动物粪便中存在人畜共患的[某种病原体名称]组合A和B。我们的研究表明,至少在这个生物群落中,蝙蝠可能在人畜共患[某种病原体名称]的传播中发挥作用。