1School of Physical Education, Liaoning Normal University; Liaoning Dalian, 116029, China.
2School of Physical Education and Health Science, Guangxi MinZu University, Guangxi Ningnin, 530000, China.
Acta Bioeng Biomech. 2024 Jan 30;25(4):35-47. doi: 10.37190/abb-02323-2023-06. Print 2023 Dec 1.
Peripheral nerve damages take place as a result of trauma, compression or disease, resulting in sensory loss, impaired motor function and subsequent challenges. In the current study, ginkgo biloba extract was loaded into PCL/gelatin scaffolds through electrospinning method. The scaffolds were characterized using various studies. The prepared nanofibrous scaffolds were rolled up to make neural guidance channels. Then, the conduits were seeded with adipose-derived stem cells and transplanted into a rat model of sciatic nerve injury. The scaffolds were not toxic and had optimal tensile and suturability. The animals treated with the conduits that delivered adipose-derived stem cells and ginkgo biloba extract, and received the treadmill exercise, had significantly higher motor and sensory functions recovery. In addition, histopathological examinations showed beneficial role of the exercise plan on the nervous system repair.
周围神经损伤是由于创伤、压迫或疾病引起的，导致感觉丧失、运动功能受损和随后的挑战。在本研究中，银杏叶提取物通过静电纺丝方法被负载到 PCL/明胶支架中。使用各种研究方法对支架进行了表征。制备的纳米纤维支架被卷起制成神经导向通道。然后，将导管接种脂肪来源的干细胞，并移植到坐骨神经损伤大鼠模型中。支架没有毒性，具有最佳的拉伸和可缝合性。接受负载脂肪来源的干细胞和银杏叶提取物的导管以及跑步机运动治疗的动物，其运动和感觉功能恢复明显更高。此外，组织病理学检查显示运动计划对神经系统修复有有益作用。
