对 COVID-19 疫苗的偏好：离散选择实验的系统文献综述。
Preferences for COVID-19 Vaccines: Systematic Literature Review of Discrete Choice Experiments.
机构信息
Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.
Department of Medical Statistics, School of Basic Medicine and Public Health, Jinan University, Guangzhou, China.
出版信息
JMIR Public Health Surveill. 2024 Jul 29;10:e56546. doi: 10.2196/56546.
BACKGROUND
Vaccination can be viewed as comprising the most important defensive barriers to protect susceptible groups from infection. However, vaccine hesitancy for COVID-19 is widespread worldwide.
OBJECTIVE
We aimed to systematically review studies eliciting the COVID-19 vaccine preference using discrete choice experiments.
METHODS
A literature search was conducted in PubMed, Embase, Web of Science, Scopus, and CINAHL Plus platforms in April 2023. Search terms included discrete choice experiments, COVID-19, and vaccines and related synonyms. Descriptive statistics were used to summarize the study characteristics. Subgroup analyses were performed by factors such as high-income countries and low- and middle-income countries and study period (before, during, and after the pandemic wave). Quality appraisal was performed using the 5-item Purpose, Respondents, Explanation, Findings, and Significance checklist.
RESULTS
The search yield a total of 623 records, and 47 studies with 53 data points were finally included. Attributes were grouped into 4 categories: outcome, process, cost, and others. The vaccine effectiveness (21/53, 40%) and safety (7/53, 13%) were the most frequently reported and important attributes. Subgroup analyses showed that vaccine effectiveness was the most important attribute, although the preference varied by subgroups. Compared to high-income countries (3/29, 10%), a higher proportion of low- and middle-income countries (4/24, 17%) prioritized safety. As the pandemic progressed, the duration of protection (2/24, 8%) during the pandemic wave and COVID-19 mortality risk (5/25, 20%) after the pandemic wave emerged as 2 of the most important attributes.
CONCLUSIONS
Our review revealed the critical role of vaccine effectiveness and safety in COVID-19 vaccine preference. However, it should be noticed that preference heterogeneity was observed across subpopulations and may change over time.
TRIAL REGISTRATION
PROSPERO CRD42023422720; https://tinyurl.com/2etf7ny7.
背景
接种疫苗可以被视为保护易感人群免受感染的最重要的防御屏障。然而，全球范围内对 COVID-19 疫苗的犹豫态度普遍存在。
目的
我们旨在系统地综述使用离散选择实验来评估 COVID-19 疫苗偏好的研究。
方法
我们于 2023 年 4 月在 PubMed、Embase、Web of Science、Scopus 和 CINAHL Plus 平台上进行了文献检索。检索词包括离散选择实验、COVID-19 和疫苗及其相关同义词。使用描述性统计来总结研究特征。亚组分析按高收入国家和中低收入国家以及研究期间（大流行前、大流行期间和大流行后）等因素进行。使用目的、受访者、解释、发现和意义检查表对质量评估进行评估。
结果
搜索共产生了 623 条记录，最终纳入了 47 项研究，共 53 个数据点。属性分为 4 类：结果、过程、成本和其他。疫苗有效性（21/53，40%）和安全性（7/53，13%）是最常报告和最重要的属性。亚组分析显示，疫苗有效性是最重要的属性，但偏好因亚组而异。与高收入国家（3/29，10%）相比，中低收入国家（4/24，17%）更重视安全性。随着大流行的进展，大流行期间的保护持续时间（2/24，8%）和大流行后 COVID-19 死亡率风险（5/25，20%）成为最重要的属性。
结论
我们的综述表明，疫苗有效性和安全性在 COVID-19 疫苗偏好中起着关键作用。然而，应该注意到，不同亚人群之间存在偏好异质性，并且可能随时间变化。
试验注册
PROSPERO CRD42023422720；https://tinyurl.com/2etf7ny7。
Zotero 插件