伴侣结合的草原田鼠的表观遗传衰老研究。

Epigenetic aging studies of pair bonding in prairie voles.

机构信息

Department of Psychology, Cornell University, Ithaca, NY, 14853, USA.

Altos Labs, San Diego, USA.

出版信息

Sci Rep. 2024 Jul 29;14(1):17439. doi: 10.1038/s41598-024-67641-2.

DOI:10.1038/s41598-024-67641-2

PMID:39075111

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11286801/

Abstract

The quality of romantic relationships can predict health consequences related to aging. DNA methylation-based biomarkers of aging accurately estimate chronological age. We developed several highly accurate epigenetic aging clocks, based on highly conserved mammalian CpGs, for the socially monogamous prairie vole (Microtus ochrogaster). In addition, our dual-species human-vole clock accurately measured relative age and illustrates high species conservation of epigenetic aging effects. Next, we assessed how pair bonding impacts epigenetic aging. We did not find evidence that pair-bonded voles exhibit accelerated or decelerated epigenetic aging effects in blood, ear, liver, or brain tissue. Our epigenome wide association study identified CpGs in five genes strongly associated with pair bonding: Foxp4, Phf2, Mms22l, Foxb1, and Eif1ad. Overall, we present accurate DNA methylation-based estimators of age for a species of great interest to researchers studying monogamy in animals. We did not find any evidence that sex-naive animals age differently from pair-bonded animals.

摘要

浪漫关系的质量可以预测与衰老相关的健康后果。基于 DNA 甲基化的衰老生物标志物可以准确估计实际年龄。我们基于高度保守的哺乳动物 CpG 开发了几种高度准确的表观遗传衰老时钟，用于社会性一夫一妻制的草原田鼠（Microtus ochrogaster）。此外，我们的双物种人类-田鼠时钟准确地测量了相对年龄，并说明了表观遗传衰老效应的高度物种保守性。接下来，我们评估了配对结合如何影响表观遗传衰老。我们没有发现证据表明配对结合的田鼠在血液、耳朵、肝脏或脑组织中表现出加速或减缓的表观遗传衰老效应。我们的全基因组关联研究鉴定了与配对结合强烈相关的五个基因中的 CpG：Foxp4、Phf2、Mms22l、Foxb1 和 Eif1ad。总的来说，我们为研究动物一夫一妻制的研究人员提供了一种对研究非常感兴趣的物种的准确基于 DNA 甲基化的年龄估算。我们没有发现任何证据表明性不成熟的动物与配对结合的动物衰老方式不同。