Naito Yoshiro, Ishihara Masaharu
Department of Cardiovascular and Renal Medicine, Hyogo Medical University, 663-8501 Nishinomiya, Japan.
Rev Cardiovasc Med. 2022 May 11;23(5):169. doi: 10.31083/j.rcm2305169. eCollection 2022 May.
Iron deficiency leads to health problems. Conversely, iron overload induces the generation of reactive oxygen species and health problems. Body iron status contributes to the development of various diseases, including aortic disease. Indeed, several clinical studies have reported that iron status can be linked to the pathogenesis of aortic disease. At the cellular level, iron uptake is regulated by the cellular iron transporter, transferrin receptor 1, while systemic iron homeostasis is regulated by hepcidin. As body iron status is regulated to maintain cellular and systemic iron homeostasis, iron metabolism in aortic disease is puzzling and not well understood.
Perspective and short communication.
This review provides an overview of the relevant research investigating the association between cellular iron metabolism and aortic disease.
缺铁会导致健康问题。相反，铁过载会诱导活性氧的产生并引发健康问题。机体铁状态会促使包括主动脉疾病在内的各种疾病的发展。事实上，多项临床研究报告称，铁状态可能与主动脉疾病的发病机制有关。在细胞水平上，铁摄取由细胞铁转运蛋白转铁蛋白受体1调节，而全身铁稳态则由铁调素调节。由于机体铁状态受到调节以维持细胞和全身铁稳态，主动脉疾病中的铁代谢令人困惑且尚未得到充分理解。
前瞻性和简短通讯。
本综述概述了有关细胞铁代谢与主动脉疾病之间关联的相关研究。
