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纳米水飞蓟素与水飞蓟素对成年雄性大鼠高脂饮食诱导的脂肪肝影响的比较

The comparison of the effects of nano-silymarin and silymarin on high-fat diet-induced fatty liver of adult male rats.

作者信息

Mohebbati Reza, Momeni-Moghaddam Mohammad Amin, Asghari Rokhsareh, Abbasnezhad Abbasali, Ebrahim Zadeh Bideskan Alireza, Salarbashi Davoud, Khajavian Nasim

机构信息

Department of Physiology, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.

Clinical Biochemistry, Faculty of Medicine, Social Determinants of Health Research Center, Gonabad University of Medical Sciences, Gonabad, Iran.

出版信息

Avicenna J Phytomed. 2024 May-Jun;14(3):365-375. doi: 10.22038/AJP.2024.23734.

DOI:10.22038/AJP.2024.23734
PMID:39086861
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11287026/
Abstract

OBJECTIVE

Considering the high prevalence of non-alcoholic fatty liver disease and its complications, this study aims to determine and compare the effect of nano-silymarin and silymarin on non-alcoholic fatty liver in rats.

MATERIALS AND METHODS

Rats were divided into 5 groups: Control, high-fat diet, high-fat diet and atorvastatin, high-fat diet and silymarin, and high-fat diet and nano-silymarin. After 12 weeks, blood samples were taken to measure cholesterol, triglyceride, HDL, LDL, ALT and AST. The animals were killed and the liver tissue was removed to examine the histopathological changes.

RESULTS

Feeding with a high-fat diet caused a significant increase in cholesterol, triglyceride and LDL-C in serum of rats compared to the control. Nano-silymarin and silymarin could significantly reduce serum triglyceride compared to negative group but the reduction of cholesterol, LDL-C, AST and ALT by nano-silymarin was not significant as compared to silymarin. The liver histology evaluation mainly showed that in the group receiving nano-silymarin, a significant decrease in the percentage of fat vacuoles and degree of steatosis was observed compared to the negative group. In the positive group, the percentage of fat vacuoles and the degree of steatosis showed a significant decrease compared to the negative group. Group receiving atorvastatin showed a greater protective effect than silymarin and nano-silymarin.

CONCLUSION

The use of nano-silymarin similar to silymarin in rats treated with a high-fat diet led to a decrease in the percentage of fat vacuoles and the degree of hepatic steatosis mainly and can be used to prevent non-alcoholic fatty liver disease.

摘要

目的

鉴于非酒精性脂肪性肝病及其并发症的高患病率，本研究旨在确定并比较纳米水飞蓟素和水飞蓟素对大鼠非酒精性脂肪肝的影响。

材料与方法

将大鼠分为5组：对照组、高脂饮食组、高脂饮食加阿托伐他汀组、高脂饮食加水飞蓟素组和高脂饮食加纳米水飞蓟素组。12周后，采集血样测定胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、谷丙转氨酶和谷草转氨酶。处死动物并取出肝脏组织检查组织病理学变化。

结果

与对照组相比，高脂饮食喂养导致大鼠血清中胆固醇、甘油三酯和低密度脂蛋白胆固醇显著升高。与阴性组相比，纳米水飞蓟素和水飞蓟素可显著降低血清甘油三酯，但与水飞蓟素相比，纳米水飞蓟素对胆固醇、低密度脂蛋白胆固醇、谷草转氨酶和谷丙转氨酶的降低作用不显著。肝脏组织学评估主要显示，与阴性组相比，接受纳米水飞蓟素的组脂肪空泡百分比和脂肪变性程度显著降低。在阳性组中，脂肪空泡百分比和脂肪变性程度与阴性组相比显著降低。接受阿托伐他汀的组显示出比水飞蓟素和纳米水飞蓟素更大的保护作用。

结论

在高脂饮食处理的大鼠中，使用与水飞蓟素类似的纳米水飞蓟素主要导致脂肪空泡百分比和肝脂肪变性程度降低，可用于预防非酒精性脂肪性肝病。

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