Cheng Jinming, Li Yan, Chen Keyang, Cao Yungang, Liu Kun, Zhang Xi, Wu Xiaoyuan, Wang Zhihong, Liu Xiaozheng, Li Litao
Department of Neurology of the Hebei Medical University, Shijiazhuang, Hebei, China.
Department of Neurology of the Hebei General Hospital, Shijiazhuang, Hebei, China.
Front Neurol. 2024 Jul 17;15:1412117. doi: 10.3389/fneur.2024.1412117. eCollection 2024.
The anterior cingulate gyrus (ACG) is an important regulatory region for pain-related information. However, the ACG is composed of subregions with different functions. The mechanisms underlying the brain networks of different subregions of the ACG in patients with migraine without aura (MwoA) are currently unclear.
In the current study, resting-state functional magnetic resonance imaging (rsfMRI) and functional connectivity (FC) were used to investigate the functional characteristics of ACG subregions in MwoA patients. The study included 17 healthy volunteers and 28 MwoA patients. The FC calculation was based on rsfMRI data from a 3 T MRI scanner. The brain networks of the ACG subregions were compared using a general linear model to see if there were any differences between the two groups. Spearman correlation analysis was used to examine the correlation between FC values in abnormal brain regions and clinical variables.
Compared with healthy subjects, MwoA patients showed decreased FC between left subgenual ACG and left middle cingulate gyrus and right middle temporal gyrus. Meanwhile, MwoA patients also showed increased FC between pregenual ACG and right angular gyrus and increased FC between right pregenual ACG and right superior occipital gyrus. The FC values between pregenual ACG and right superior occipital gyrus were significantly positively correlated with the visual analogue scale.
Disturbances of FC between ACG subregions and default model network and visual cortex may play a key role in neuropathological features, perception and affection of MwoA. The current study provides further insights into the complex scenario of MwoA mechanisms.
前扣带回皮质（ACG）是疼痛相关信息的重要调节区域。然而，ACG由具有不同功能的亚区域组成。目前尚不清楚无先兆偏头痛（MwoA）患者ACG不同亚区域脑网络的潜在机制。
在本研究中，采用静息态功能磁共振成像（rsfMRI）和功能连接（FC）来研究MwoA患者ACG亚区域的功能特征。该研究纳入了17名健康志愿者和28名MwoA患者。FC计算基于3T MRI扫描仪的rsfMRI数据。使用一般线性模型比较ACG亚区域的脑网络，以观察两组之间是否存在差异。采用Spearman相关分析来检验异常脑区FC值与临床变量之间的相关性。
与健康受试者相比，MwoA患者左膝下ACG与左中扣带回皮质及右颞中回之间的FC降低。同时，MwoA患者膝前ACG与右角回之间的FC增加，右膝前ACG与右枕上回之间的FC也增加。膝前ACG与右枕上回之间的FC值与视觉模拟量表显著正相关。
ACG亚区域与默认模式网络及视觉皮质之间的FC紊乱可能在MwoA的神经病理特征、感知和情感方面起关键作用。本研究为MwoA机制的复杂情况提供了进一步的见解。
