Wang Xinyu, Zhang Qian, Xu Rongxuan, Li Xiaofeng, Hong Zhijun
The Health Management Center, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Department of Public Health, Dalian Medical University, Dalian, Liaoning, China.
Front Oncol. 2024 Jul 17;14:1416806. doi: 10.3389/fonc.2024.1416806. eCollection 2024.
Colorectal cancer (CRC) is one of the most common gastrointestinal malignancies in the world. With the rapid pace of life and changes in diet structure, the incidence and mortality of CRC increase year by year posing a serious threat to human health. As the most complex and largest microecosystem in the human body, intestinal microecology is closely related to CRC. It is an important factor that affects and participates in the occurrence and development of CRC. Advances in next-generation sequencing technology and metagenomics have provided new insights into the ecology of gut microbes. It also helps to link intestinal flora with CRC, and the relationship between intestinal flora and CRC can be continuously understood from different levels. This paper summarizes the relationship between intestinal flora and CRC and its potential role in the diagnosis of CRC providing evidence for early screening and treatment of CRC.
结直肠癌（CRC）是世界上最常见的胃肠道恶性肿瘤之一。随着生活节奏的加快和饮食结构的变化，CRC的发病率和死亡率逐年上升，对人类健康构成严重威胁。肠道微生态作为人体最复杂、最大的微生态系统，与CRC密切相关。它是影响和参与CRC发生发展的重要因素。新一代测序技术和宏基因组学的进展为肠道微生物生态学提供了新的见解。它还有助于将肠道菌群与CRC联系起来，并能从不同层面不断了解肠道菌群与CRC之间的关系。本文综述了肠道菌群与CRC的关系及其在CRC诊断中的潜在作用，为CRC的早期筛查和治疗提供依据。
