Li Rongrong, Shen Jilu, Xu Yuanhong
Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, People's Republic of China.
Department of Clinical Laboratory, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, 230012, People's Republic of China.
Infect Drug Resist. 2022 Mar 17;15:1115-1120. doi: 10.2147/IDR.S357922. eCollection 2022.
() is an oral anaerobic gram-negative bacillus that can colonize into the colon tissues through bloodstream infection. have been found to be involved in both the occurrence and metastasis of colorectal cancer (CRC) through regulating immune response, virulence factor, oncogenic microRNAs, intestinal metabolites, DNA damage and other mechanisms. Therefore, can be as an important pathogenic risk factor and a possible biomarker of CRC. Based on this, we have summarized the potential relationship between and CRC to provide reference for the targeted therapy of CRC.
（）是一种口腔厌氧革兰氏阴性杆菌，可通过血流感染定植于结肠组织。已发现其通过调节免疫反应、毒力因子、致癌微小RNA、肠道代谢产物、DNA损伤等机制参与结直肠癌（CRC）的发生和转移。因此，（）可作为CRC的重要致病危险因素和潜在生物标志物。基于此，我们总结了（）与CRC之间的潜在关系，为CRC的靶向治疗提供参考。
