Liu Yujing, Zhang Shengan, Zhou Wenjun, Hu Dan, Xu Hanchen, Ji Guang
Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Department of Internal Medicine of Chinese Medicine, Shanghai Pudong New Area Hospital of Traditional Chinese Medicine, Shanghai, China.
Front Oncol. 2022 Apr 28;12:813745. doi: 10.3389/fonc.2022.813745. eCollection 2022.
Colorectal cancer (CRC) is one of the most common and deadly cancers in the world and is a typical inflammatory tumor. In recent years, the incidence of CRC has been increasing year by year. There is evidence that the intake of high-fat diet and overweight are associated with the incidence of CRC, among which bile acids play a key role in the pathogenesis of the disease. Studies on the relationship between bile acid metabolism and the occurrence of CRC have gradually become a hot topic, improving the understanding of metabolic factors in the etiology of colorectal cancer. Meanwhile, intestinal flora also plays an important role in the occurrence and development of CRC In this review, the classification of bile acids and their role in promoting the occurrence of CRC are discussed, and we highlights how a high-fat diet affects bile acid metabolism and destroys the integrity of the intestinal barrier and the effects of gut bacteria.
结直肠癌（CRC）是世界上最常见且致命的癌症之一，是一种典型的炎症性肿瘤。近年来，CRC的发病率逐年上升。有证据表明，高脂肪饮食的摄入和超重与CRC的发病率相关，其中胆汁酸在该疾病的发病机制中起关键作用。关于胆汁酸代谢与CRC发生之间关系的研究逐渐成为一个热门话题，这增进了人们对结直肠癌病因中代谢因素的理解。同时，肠道菌群在CRC的发生和发展中也起着重要作用。在这篇综述中，我们讨论了胆汁酸的分类及其在促进CRC发生中的作用，并强调了高脂肪饮食如何影响胆汁酸代谢、破坏肠道屏障的完整性以及肠道细菌的作用。
