Faculty of Medicine, University of Jordan, Amman, Jordan.
Dermatol Online J. 2024 Jun 15;30(3). doi: 10.5070/D330363865.
Lichen sclerosus (LS) is a chronic inflammatory dermatosis primarily affecting the genitalia, commonly characterized by pearly-white papules and plaques. Although predominantly affecting females, LS can manifest across all age groups, with a bimodal distribution observed in prepubescent girls and postmenopausal women. This case report presents an unusual instance of exclusive extragenital LS in a 10-year-old girl, showcasing hyperpigmented patches and wrinkled plaques resembling lichen planus on her forearms and lower legs. Histopathological analysis confirmed LS, revealing distinctive epidermal changes and lymphocytic infiltrates. The absence of mucosal involvement and unique clinical presentation differentiated this case from typical LS manifestations. Treatment with topical clobetasol propionate demonstrated significant improvement in pruritus. Extragenital LS is infrequent, particularly among children, and its diagnosis necessitates a comprehensive clinicopathological correlation. The reported case contributes valuable insights into this uncommon variant, emphasizing the importance of accurate diagnosis and tailored treatment strategies. Additionally, it highlights the efficacy of high-potency topical corticosteroids in managing this condition.
硬化性苔藓(LS)是一种主要影响生殖器的慢性炎症性皮肤病,通常表现为珍珠白色丘疹和斑块。尽管主要影响女性,但 LS 可发生于所有年龄段,在青春期前女孩和绝经后妇女中观察到双峰分布。本病例报告介绍了一例 10 岁女孩罕见的单纯性外阴 LS,其前臂和小腿出现色素沉着斑块和类似扁平苔藓的皱缩斑块。组织病理学分析证实为 LS,显示出独特的表皮变化和淋巴细胞浸润。无黏膜受累和独特的临床表现将此病例与典型 LS 表现区分开来。局部应用丙酸氯倍他索治疗瘙痒显著改善。外阴 LS 较为罕见,特别是在儿童中,其诊断需要全面的临床病理相关性。所报告的病例为这种罕见变异提供了有价值的见解,强调了准确诊断和制定个体化治疗策略的重要性。此外,它还强调了高效局部皮质类固醇治疗这种疾病的疗效。