Suppr超能文献

儿童局限性外阴硬化性苔藓呈扁平苔藓样分布

Exclusive extragenital lichen sclerosis in a child presenting in a lichen planus distribution.

机构信息

Faculty of Medicine, University of Jordan, Amman, Jordan.

出版信息

Dermatol Online J. 2024 Jun 15;30(3). doi: 10.5070/D330363865.

Abstract

Lichen sclerosus (LS) is a chronic inflammatory dermatosis primarily affecting the genitalia, commonly characterized by pearly-white papules and plaques. Although predominantly affecting females, LS can manifest across all age groups, with a bimodal distribution observed in prepubescent girls and postmenopausal women. This case report presents an unusual instance of exclusive extragenital LS in a 10-year-old girl, showcasing hyperpigmented patches and wrinkled plaques resembling lichen planus on her forearms and lower legs. Histopathological analysis confirmed LS, revealing distinctive epidermal changes and lymphocytic infiltrates. The absence of mucosal involvement and unique clinical presentation differentiated this case from typical LS manifestations. Treatment with topical clobetasol propionate demonstrated significant improvement in pruritus. Extragenital LS is infrequent, particularly among children, and its diagnosis necessitates a comprehensive clinicopathological correlation. The reported case contributes valuable insights into this uncommon variant, emphasizing the importance of accurate diagnosis and tailored treatment strategies. Additionally, it highlights the efficacy of high-potency topical corticosteroids in managing this condition.

摘要

硬化性苔藓(LS)是一种主要影响生殖器的慢性炎症性皮肤病,通常表现为珍珠白色丘疹和斑块。尽管主要影响女性,但 LS 可发生于所有年龄段,在青春期前女孩和绝经后妇女中观察到双峰分布。本病例报告介绍了一例 10 岁女孩罕见的单纯性外阴 LS,其前臂和小腿出现色素沉着斑块和类似扁平苔藓的皱缩斑块。组织病理学分析证实为 LS,显示出独特的表皮变化和淋巴细胞浸润。无黏膜受累和独特的临床表现将此病例与典型 LS 表现区分开来。局部应用丙酸氯倍他索治疗瘙痒显著改善。外阴 LS 较为罕见,特别是在儿童中,其诊断需要全面的临床病理相关性。所报告的病例为这种罕见变异提供了有价值的见解,强调了准确诊断和制定个体化治疗策略的重要性。此外,它还强调了高效局部皮质类固醇治疗这种疾病的疗效。

相似文献

2
Oral and Vulvar Lichen Sclerosus.口腔和外阴硬化性苔藓
Acta Dermatovenerol Croat. 2019 Sep;27(3):195-197.
3
Extragenital lichen sclerosus: A comprehensive review.生殖器外硬化性苔藓:全面综述。
Australas J Dermatol. 2022 Nov;63(4):452-462. doi: 10.1111/ajd.13890. Epub 2022 Aug 11.
5
Nail dystrophy due to lichen sclerosus?由硬化性苔藓引起的甲营养不良?
Clin Exp Dermatol. 2001 Sep;26(6):507-9. doi: 10.1046/j.1365-2230.2001.00878.x.
6
Extragenital bullous lichen sclerosus.生殖器外大疱性硬化性苔藓
Dermatol Online J. 2015 Dec 16;21(12):13030/qt1rc0z3n8.
7
Topical interventions for genital lichen sclerosus.生殖器硬化性苔藓的局部干预措施。
Cochrane Database Syst Rev. 2011 Dec 7;2011(12):CD008240. doi: 10.1002/14651858.CD008240.pub2.

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验