Zhu Xing-Yun, Xiong Yu-Jun, Meng Xiang-Da, Xu Hua-Zhao, Huo Lili, Deng Wei
Department of Endocrinology, Beijing Jishuitan Hospital, Capital Medical University, No. 31, East Xinjiekou Street, Xicheng District, Beijing, 100035, People's Republic of China.
Department of Gastroenterology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100370, P.R. China.
Diabetol Metab Syndr. 2024 Aug 1;16(1):187. doi: 10.1186/s13098-024-01422-9.
Limited research has explored the potential association between the Triglyceride-Glucose (TyG) and mortality, especially in individuals with Helicobacter pylori (H. pylori) infection. This study seeks to investigate the correlation between the TyG index and H. pylori infection and investigate whether the associations between the TyG index exposure and all-cause mortality are mediated by H. pylori infection.
The study utilized data from the National Health and Nutrition Examination Survey (NHANES) 1999-2018, incorporating a final sample size of 2,187 participants. Both univariable and multivariable-adjusted logistic regression analyses were employed to examine the relationship between H. pylori infection and relevant covariates. To assess the association between TyG index, and all-cause mortality in individuals with or without H. pylori infection, Cox regression analysis, and restricted regression cubic spline analysis were implemented.
A significant positive correlation was observed between the TyG index and an elevated risk of H. pylori infection [OR 1.157, 95% CI (1.383 ~ 1.664)]. This correlation persisted even after adjusting for confounding factors [OR 1.189, 95% CI (1.003, 1.411), P < 0.05]. Furthermore, in patients with positive H. pylori infection, a noteworthy nonlinear correlation between the TyG index and all-cause mortality was identified (P = 0.0361). With an increase in the TyG index, all-cause mortality exhibited a corresponding rise, particularly following adjustment for all potential confounding factors. Conversely, in patients with negative H. pylori infection, no significant association was observed between the TyG index and all-cause mortality after adjusting for potential confounding factors.
A higher TyG index was linked to increased H. pylori infection risks. Participants in the higher quantile group of the TyG index are positively associated with higher all-cause mortality compared to the higher quantile group of the TyG index in H. pylori-positive participants instead of H. pylori-negative participants.
有限的研究探讨了甘油三酯-葡萄糖（TyG）与死亡率之间的潜在关联，尤其是在幽门螺杆菌（H. pylori）感染个体中。本研究旨在调查TyG指数与幽门螺杆菌感染之间的相关性，并研究TyG指数暴露与全因死亡率之间的关联是否由幽门螺杆菌感染介导。
该研究利用了1999 - 2018年国家健康与营养检查调查（NHANES）的数据，最终样本量为2187名参与者。采用单变量和多变量调整的逻辑回归分析来检验幽门螺杆菌感染与相关协变量之间的关系。为了评估TyG指数与有无幽门螺杆菌感染个体的全因死亡率之间的关联，实施了Cox回归分析和受限回归立方样条分析。
观察到TyG指数与幽门螺杆菌感染风险升高之间存在显著正相关[比值比（OR）1.157，95%置信区间（CI）（1.383～1.664）]。即使在调整混杂因素后，这种相关性仍然存在[OR 1.189，95% CI（1.003，1.411），P < 0.05]。此外，在幽门螺杆菌感染阳性患者中，发现TyG指数与全因死亡率之间存在显著的非线性相关性（P = 0.0361）。随着TyG指数的增加，全因死亡率相应上升，尤其是在调整所有潜在混杂因素之后。相反，在幽门螺杆菌感染阴性患者中，调整潜在混杂因素后，未观察到TyG指数与全因死亡率之间存在显著关联。
较高的TyG指数与幽门螺杆菌感染风险增加有关。与幽门螺杆菌阴性参与者相比，TyG指数较高分位数组的参与者与较高的全因死亡率呈正相关，而非幽门螺杆菌阳性参与者中TyG指数较高分位数组。
