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上皮样血管内皮瘤：一例报告

Epithelioid hemangioendothelioma: a case report.

作者信息

Park Sat Byul, Kim Young Bae, You Seulgi

机构信息

Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Korea.

Department of Pathology, Ajou University School of Medicine, Suwon, Korea.

出版信息

AME Case Rep. 2024 Jun 14;8:65. doi: 10.21037/acr-23-51. eCollection 2024.

DOI:10.21037/acr-23-51
PMID:39091552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11292091/
Abstract

BACKGROUND

Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor with limited clinical data that can guide treatment choices. The diagnosis of EHE is based on its unique histological, immunohistochemical, and molecular characteristics. Differential diagnoses are broad and include autoimmune diseases. Treatments include hepatic resection, liver transplantation, systemic/regional chemotherapy, and radiotherapy.

CASE DESCRIPTION

We describe EHE in a patient with weight loss and general weakness. The prognosis of EHE is variable, with few cases demonstrating an indolent clinical course, whereas others tend to metastasize. In our case, hepatic EHE had metastasized to the lungs and brain. Histopathological examination of the liver tissue revealed an epithelial hemangioendothelioma. On CK7 staining, hepatocytes were clearly reactive and arranged in the plates (CK7: negative), with positive immunohistochemical staining for CD34 (CD34: positive) alone. Surveillance was conducted and the clinical course was better than expected, probably due to her relatively good general condition, the lack of genetic factors associated with her familial medical history, and normal levels of tumor markers such as α-fetoprotein and carcinoembryonic antigen (CEA). During a follow-up examination, she was asymptomatic with a healthy general appearance.

CONCLUSIONS

The prognosis of EHE is variable, with few cases demonstrating an indolent clinical course, whereas others tend to metastasize. The treatment method for EHE should be determined according to the patient's condition.

摘要

背景

上皮样血管内皮瘤（EHE）是一种罕见的血管肿瘤，临床数据有限，难以指导治疗方案的选择。EHE的诊断基于其独特的组织学、免疫组化和分子特征。鉴别诊断范围广泛，包括自身免疫性疾病。治疗方法包括肝切除术、肝移植、全身/区域化疗和放疗。

病例描述

我们描述了一名体重减轻、全身乏力患者的EHE情况。EHE的预后各不相同，少数病例临床病程呈惰性，而其他病例则易于发生转移。在我们的病例中，肝脏EHE已转移至肺和脑。肝组织的组织病理学检查显示为上皮样血管内皮瘤。CK7染色时，肝细胞呈明显反应性并呈板状排列（CK7：阴性），仅CD34免疫组化染色呈阳性（CD34：阳性）。进行了监测，临床病程比预期的要好，这可能是由于她的一般状况相对良好、家族病史中缺乏相关遗传因素以及甲胎蛋白和癌胚抗原（CEA）等肿瘤标志物水平正常。在后续检查中，她无症状，整体外观健康。

结论

EHE的预后各不相同，少数病例临床病程呈惰性，而其他病例则易于发生转移。EHE的治疗方法应根据患者的病情确定。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef7/11292091/8e6189d063b2/acr-08-23-51-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef7/11292091/1379e1130f0d/acr-08-23-51-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef7/11292091/ea6b77f3457b/acr-08-23-51-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef7/11292091/d4cae792b104/acr-08-23-51-f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef7/11292091/acb46b4fae89/acr-08-23-51-f12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef7/11292091/569dddfab854/acr-08-23-51-f13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef7/11292091/29511ff6a0c8/acr-08-23-51-f14.jpg
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2
Typical CT and MRI signs of hepatic epithelioid hemangioendothelioma.肝上皮样血管内皮瘤的典型CT和MRI表现。
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3
Epithelioid hemangioendothelioma: an overview and update on a rare vascular tumor.上皮样血管内皮瘤：一种罕见血管肿瘤的概述与更新
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4
Epithelioid hemangioendothelioma of the liver.肝脏上皮样血管内皮瘤
Clin Mol Hepatol. 2013 Sep;19(3):315-9. doi: 10.3350/cmh.2013.19.3.315.
5
Clinical experience with primary hepatic epithelioid hemangioendothelioma: retrospective study of 33 patients.原发性肝脏上皮样血管内皮细胞瘤的临床经验：33 例回顾性研究。
World J Surg. 2012 Nov;36(11):2677-83. doi: 10.1007/s00268-012-1714-x.
6
Pulmonary epithelioid hemangioendothelioma.肺上皮样血管内皮瘤
Isr Med Assoc J. 2011 Nov;13(11):676-9.
7
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8
CT and MRI diagnosis of hepatic epithelioid hemangioendothelioma.CT 和 MRI 诊断肝上皮样血管内皮细胞瘤。
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10
Imaging of liver metastases: MRI.肝转移瘤的影像学检查：磁共振成像（MRI）
Cancer Imaging. 2007;7(1):2-9. doi: 10.1102/1470-7330.2007.0002.