Trape J F, Fribourg-Blanc A, Bosseno M F, Lallemant M, Engler R, Mouchet J
Trans R Soc Trop Med Hyg. 1985;79(4):430-4. doi: 10.1016/0035-9203(85)90053-7.
The lack of serum haptoglobin in Africans has been investigated in the Congo, Central Africa, where HpO prevalence is about 30%. This study shows that it is possible to suppress ahaptoglobinaemia within a few weeks by antimalarial chemoprophylaxis, that it does not occur in protected individuals, that ahaptoglobinaemia reappears at its original incidence levels after interruption of chemoprophylaxis, and that some individuals are more susceptible in relation to Hp2 gene. Malaria is the only significant cause of ahaptoglobinaemia in subjects both with and without detectable parasitaemia. The possible mechanisms involved are discussed.
在非洲中部的刚果，对当地非洲人血清中缺乏触珠蛋白的情况进行了调查，那里触珠蛋白O（HpO）的流行率约为30%。这项研究表明，通过抗疟化学预防措施有可能在几周内抑制无触珠蛋白血症，在受到保护的个体中不会出现无触珠蛋白血症，化学预防措施中断后，无触珠蛋白血症会以其原来的发病率再次出现，并且一些个体相对于Hp2基因更易感染。疟疾是有或没有可检测到的寄生虫血症的受试者中无触珠蛋白血症的唯一重要原因。文中讨论了可能涉及的机制。
