Rosa-Fernandes Lívia, Santiago Verônica Feijoli, da Silva-Santos Yasmin, Lopes Tissiane Tarosso, Peixoto Erika Paula Machado, Rodrigues Stefani Aparecida Minchio, Marinho Claudio Romero Farias, Palmisano Giuseppe, Epiphanio Sabrina
Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
J Immunol Res. 2025 Mar 23;2025:5642957. doi: 10.1155/jimr/5642957. eCollection 2025.
Malaria is a parasitic infectious disease considered a public health problem. Acute respiratory distress syndrome (ARDS) is a complication in malaria-infected individuals with a high mortality rate (80% to 100%) and can occur before, during, or after antimalarial drug treatment. Although inflammation and epithelial/endothelial injury pathways have been determined through these studies, specific circulating malaria-associated ARDS markers have not yet been established. We applied a quantitative mass spectrometry (MS)-based proteomic approach to identify altered molecular pathways in a mouse model of malaria-associated ARDS. Acute-phase response (APR) proteins were regulated in the ARDS group, suggesting their potential involvement in the development of the syndrome. They may serve as biomarkers when analyzed alongside other proteins that require further investigation. Additionally, the regulation of APR proteins in the ARDS group provides valuable insights into the pathophysiology of ARDS, contributing to a better understanding of the syndrome.
疟疾是一种被视为公共卫生问题的寄生虫感染性疾病。急性呼吸窘迫综合征（ARDS）是疟疾感染个体中的一种并发症，死亡率很高（80%至100%），可在抗疟药物治疗前、治疗期间或治疗后发生。尽管通过这些研究已经确定了炎症和上皮/内皮损伤途径，但尚未建立特定的与疟疾相关的ARDS循环标志物。我们应用基于定量质谱（MS）的蛋白质组学方法来鉴定疟疾相关ARDS小鼠模型中改变的分子途径。急性期反应（APR）蛋白在ARDS组中受到调节，表明它们可能参与了该综合征的发展。当与其他需要进一步研究的蛋白质一起分析时，它们可能作为生物标志物。此外，ARDS组中APR蛋白的调节为ARDS的病理生理学提供了有价值的见解，有助于更好地理解该综合征。
