Liu Lingxiao, Liu Zhiwei, Xu Xinrui, Wang Jiang, Tong Zhaoyang
State Key Laboratory of NBC Protection for Civilian, Beijing, 102205, China.
State Key Laboratory of NBC Protection for Civilian, Beijing, 102205, China.
Talanta. 2024 Nov 1;279:126615. doi: 10.1016/j.talanta.2024.126615. Epub 2024 Aug 2.
The sensitive detection of analytes of different sizes is crucial significance for environmental protection, food safety and medical diagnostics. The confined space of nanochannels provides a location closest to the molecular reaction behaviors in real systems, thereby opening new opportunities for the precise detection of analytes. However, due to the susceptibility to external interference on the confined space of nanochannels, the high sensitivity nature of the current signals through the nanochannels is more troubling for the detection reliability. Combining highly sensitive optical signals with the sensitive current signals of solid-state nanochannels establishes a nanochannel detection platform based on electro-optical dual signals, potentially offering more sensitive, specific, and accuracy detection of analytes. This review summarizes the last five years of applications of solid-state nanochannels based on electro-optical dual signals in analytes detection. Firstly, the detection principles of solid-state nanochannels and the construction strategies of nanochannel electro-optical sensing platforms are discussed. Subsequently, the review comprehensively outlines the applications involving nanochannels with electrical signals combined with fluorescence signals, electrical signals combined with surface-enhanced Raman spectroscopy signals, and electrical signals combined with other optical signals in analyte detection. Additionally, the perspectives and difficulties of nanochannels are investigated on the basis of electro-optical dual signals.
对不同大小分析物的灵敏检测对于环境保护、食品安全和医学诊断具有至关重要的意义。纳米通道的受限空间提供了最接近实际系统中分子反应行为的场所，从而为分析物的精确检测带来了新机遇。然而，由于纳米通道受限空间易受外部干扰，通过纳米通道的电流信号的高灵敏度特性对检测可靠性而言更具困扰性。将高灵敏的光信号与固态纳米通道的灵敏电流信号相结合，建立了基于电光双信号的纳米通道检测平台，有望实现对分析物更灵敏、特异和准确的检测。本综述总结了基于电光双信号的固态纳米通道在分析物检测方面过去五年的应用情况。首先，讨论了固态纳米通道的检测原理以及纳米通道电光传感平台的构建策略。随后，该综述全面概述了在分析物检测中涉及电信号与荧光信号相结合、电信号与表面增强拉曼光谱信号相结合以及电信号与其他光信号相结合的纳米通道的应用。此外，基于电光双信号对纳米通道的前景和困难进行了研究。
