College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan, 430070, China.
Institute of Dairy Science, MoE Key Laboratory of Molecular Animal Nutrition, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China.
Mol Nutr Food Res. 2024 Sep;68(17):e2400251. doi: 10.1002/mnfr.202400251. Epub 2024 Aug 4.
Bioactive peptides (BPs) are protein fragments with beneficial effects on metabolism, physiology, and diseases. This review focuses on proteolytic BPs, which are produced by the action of gut microbiota on proteins in food and have demonstrated to influence the composition of gut microbes. And gut microbiota are candidate targets of BPs to alleviate oxidative stress, enhance immunity, and control diseases, including diabetes, hypertension, obesity, cancer, and immune and neurodegenerative diseases. Despite promising results, further research is needed to understand the mechanisms underlying the interactions between BPs and gut microbes, and to identify and screen more BPs for industrial applications. Overall, BPs offer potential as therapeutic agents for various diseases through their interactions with gut microbes, highlighting the importance of continued research in this area.
生物活性肽（BPs）是具有代谢、生理和疾病有益作用的蛋白质片段。本综述重点介绍了蛋白水解 BPs，它们是由肠道微生物对食物中蛋白质的作用产生的，已证明它们可以影响肠道微生物的组成。肠道微生物是 BPs 缓解氧化应激、增强免疫力和控制疾病（包括糖尿病、高血压、肥胖、癌症以及免疫和神经退行性疾病）的候选靶点。尽管有很有前景的结果，但仍需要进一步研究以了解 BPs 与肠道微生物相互作用的机制，并鉴定和筛选更多用于工业应用的 BPs。总的来说，BPs 通过与肠道微生物的相互作用为各种疾病提供了治疗的可能性，这突显了该领域持续研究的重要性。
