M Hamzah Aseel, N Dawood Tamara
Zoonotic Disease Unit, Veterinary Medicine College, Baghdad University, Baghdad, Iraq.
Department of Public Health, College of Veterinary Medicine, Baghdad University, Baghdad, Iraq.
J Adv Vet Anim Res. 2024 Jun 8;11(2):367-375. doi: 10.5455/javar.2024.k785. eCollection 2024 Jun.
The goal of this research was to evaluate where selenium nanoparticles impact the activity of antibodies in immunized lambs with foot and mouth vaccines by modulating the immune system.
Two groups of lambs of 3-4 months of age were injected with 1 ml of ARRIAH-VAC vaccine intramuscularly in the neck, five Lambs were given selenium nanoparticles (size 100 nm) oral administration of selenium nano dose of 0.1 mg/kg of body mass once every day for sixty days considered as group one (G1) while the other five used as control Group 2 (G2).
This resulted in the establishment of an immune response, as evidenced by a rise in antibody titer in the blood using the ELISA test for three serotypes A, O, and Asia 1, when selenium nanoparticles were given orally at a dose of 0.1 mg/kg body weight after immunization, we noticed a significant ( >0:05) selenium nano group increase in IgG response in all immunized groups in contrast to lambs that had only received the foot-and-mouth disease vaccine.
We have demonstrated that selenium nanoparticles administered orally significantly enhance immune responses while also increasing body weight.
本研究的目的是评估硒纳米颗粒通过调节免疫系统对口蹄疫疫苗免疫的羔羊抗体活性的影响。
两组3至4月龄的羔羊在颈部肌肉注射1毫升ARRIAH-VAC疫苗，五头羔羊每天口服一次硒纳米颗粒（尺寸为100纳米），硒纳米剂量为0.1毫克/千克体重，持续60天，作为第一组（G1），另外五头作为对照组2（G2）。
这导致了免疫反应的建立，通过ELISA试验检测血液中A、O和亚洲1型三种血清型的抗体滴度升高得以证明。当免疫后以0.1毫克/千克体重的剂量口服硒纳米颗粒时，我们注意到与仅接受口蹄疫疫苗的羔羊相比，所有免疫组中硒纳米组的IgG反应显著（>0.05）增加。
我们已经证明，口服硒纳米颗粒可显著增强免疫反应，同时还能增加体重。
