Xiangya Nursing School, Central South University, Changsha, Hunan, China.
The Third Xiangya Hospital, Central South University, Changsha, Hunan, China; Medical Ozone Research Center of Central South University, Changsha, Hunan, China.
Acta Derm Venereol. 2024 Aug 5;104:adv35427. doi: 10.2340/actadv.v104.35427.
The pattern of itching in patients with atopic dermatitis has not been systematically studied. Therefore, this study aimed to assess the pattern of itching in adults with atopic dermatitis using questionnaires to assess for a circadian rhythm of itching in participating patients at a single institution (n = 241). A self-report questionnaire was used to assess circadian rhythm and intensity of itching in patients. In addition, the patients' disease severity (Eczema Area and Severity Index [EASI]) and quality of life (Dermatology Life Quality Index [DLQI]) were assessed. Itching occurred most frequently (74.69%) and with the greatest severity (62.66%) between 20:00 and 00:00, and the least number of patients (25.31%) experienced itching between 04:00 and 08:00. The DLQI and EASI scores both correlated with the average and maximum itch intensity (r = 0.582, r = 0.533, respectively; r = 0.539, r = 0.517, respectively; p < 0.001). The DLQI and EASI scores were associated with average itch intensity (B = 0.179, B = 0.204, respectively; 95% CI: 0.112 to 0.246, 95% CI: 0.096 to 0.313, respectively; p < 0.001), and the EASI score was associated with males and family history (B = 0.285, B = 0.287, respectively; 95% CI: 0.094 to 0.476, 95% CI: 0.096 to 0.478, respectively; p = 0.003). Adult patients with atopic dermatitis exhibited a circadian rhythm of itching; these study results could positively impact treatment approaches.
特应性皮炎患者的瘙痒模式尚未得到系统研究。因此，本研究旨在评估单机构参与患者的瘙痒昼夜节律（n=241），使用评估瘙痒昼夜节律和强度的问卷评估特应性皮炎成人的瘙痒模式。使用自我报告问卷评估患者的昼夜节律和瘙痒强度。此外，还评估了患者的疾病严重程度（Eczema Area and Severity Index [EASI]）和生活质量（Dermatology Life Quality Index [DLQI]）。瘙痒最常发生（74.69%）且最严重（62.66%）的时间在 20:00 至 00:00 之间，而最少的患者（25.31%）在 04:00 至 08:00 之间出现瘙痒。DLQI 和 EASI 评分均与平均和最大瘙痒强度相关（r=0.582，r=0.533；r=0.539，r=0.517；p<0.001）。DLQI 和 EASI 评分与平均瘙痒强度相关（B=0.179，B=0.204；95%CI：0.112 至 0.246；95%CI：0.096 至 0.313；p<0.001），EASI 评分与男性和家族史相关（B=0.285，B=0.287；95%CI：0.094 至 0.476；95%CI：0.096 至 0.478；p=0.003）。特应性皮炎成人患者表现出瘙痒昼夜节律；这些研究结果可能对治疗方法产生积极影响。
