Choi H S, Anderson P J
Am J Clin Pathol. 1979 Dec;72(6):931-43. doi: 10.1093/ajcp/72.6.931.
Seven hundred seventy-five cerebrospinal fluid samples from 748 patients with neurologic and non-neurologic disorders were studied by a modified cytocentrifuge technic for diagnostic evaluation. The technic proved to be simple, rapid, and inexpensive, and provided consistently good artifact-free morphologic detail suitable for differential and cytochemical analysis. Specimens from 525 patients (70%) had normal cytologic characteristics regardless of underlying condition. Examination of the cerebrospinal fluids of 40 patients (5%) revealed hemorrhage, confirming the presence of intracranial hemorrhage. Inflammatory reactions of various types (acute, chronic, and mixed) were encountered in 120 patients (16%). The appearance of neoplastic cells in cerebrospinal fluid was sometimes the first indication of malignancy. Twenty-six patients (4%) had tumor cells of various types in their cerebrospinal fluids on initial examination. Twenty patients (3%) had abnormal cells initially classified as suspect for malignancy; tumor cells subsequently were found in the spinal fluids of 11 of these, while five were proven to have neoplasms at autopsy without having had tumor cells found in their cerebrospinal fluids. There was no false-positive result. Samples of cerebrospinal fluid from 17 patients (2%) were classified as non-diagnostic, usually because of autolysis.
采用改良的细胞离心技术对748例患有神经和非神经疾病患者的775份脑脊液样本进行了诊断评估研究。该技术被证明简单、快速且成本低廉，并能始终提供适合鉴别和细胞化学分析的无假象的良好形态学细节。525例患者（70%）的样本无论潜在病情如何，其细胞学特征均正常。40例患者（5%）的脑脊液检查发现有出血，证实存在颅内出血。120例患者（16%）出现了各种类型的炎症反应（急性、慢性和混合性）。脑脊液中肿瘤细胞的出现有时是恶性肿瘤的首个迹象。26例患者（4%）初次检查时脑脊液中有各种类型的肿瘤细胞。20例患者（3%）的细胞异常最初被归类为疑似恶性肿瘤；随后在其中11例患者的脑脊液中发现了肿瘤细胞，而5例在尸检时被证实患有肿瘤，但脑脊液中未发现肿瘤细胞。没有假阳性结果。17例患者（2%）的脑脊液样本被归类为无法诊断，通常是由于自溶。
